• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脓毒症中的线粒体功能障碍与免疫细胞代谢

Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis.

作者信息

Park Dae Won, Zmijewski Jaroslaw W

机构信息

Division of Infectious Diseases, Korea University Ansan Hospital, Ansan, Korea.

Division of Pulmonary, Allergy & Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

出版信息

Infect Chemother. 2017 Mar;49(1):10-21. doi: 10.3947/ic.2017.49.1.10.

DOI:10.3947/ic.2017.49.1.10
PMID:28378540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5382045/
Abstract

Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities.

摘要

脓毒症是一种由全身感染介导，但也可由出血和创伤引发的危及生命的病症。这些是导致器官损伤的重要原因，与发病率和死亡率相关，以及与先天性和适应性免疫功能障碍相关的脓毒症后并发症。细胞生物能量学和免疫细胞代谢可塑性丧失在脓毒症发病机制中的作用日益凸显。本综述描述了脓毒症导致的免疫细胞线粒体生物学和代谢改变，并指出了可能的治疗机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2607/5382045/61ae906fa001/ic-49-10-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2607/5382045/2dee9f642031/ic-49-10-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2607/5382045/90677074851f/ic-49-10-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2607/5382045/61ae906fa001/ic-49-10-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2607/5382045/2dee9f642031/ic-49-10-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2607/5382045/90677074851f/ic-49-10-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2607/5382045/61ae906fa001/ic-49-10-g003.jpg

相似文献

1
Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis.脓毒症中的线粒体功能障碍与免疫细胞代谢
Infect Chemother. 2017 Mar;49(1):10-21. doi: 10.3947/ic.2017.49.1.10.
2
Biology and Metabolism of Sepsis: Innate Immunity, Bioenergetics, and Autophagy.脓毒症的生物学与代谢：固有免疫、生物能量学及自噬
Surg Infect (Larchmt). 2016 Jun;17(3):286-93. doi: 10.1089/sur.2015.262. Epub 2016 Apr 19.
3
Emerging roles of mitochondria and autophagy in liver injury during sepsis.线粒体与自噬在脓毒症肝损伤中的新作用
Cell Stress. 2017 Oct 2;1(2):79-89. doi: 10.15698/cst2017.11.110.
4
Mitochondrial Mechanisms in Septic Cardiomyopathy.脓毒症性心肌病中的线粒体机制
Int J Mol Sci. 2015 Aug 3;16(8):17763-78. doi: 10.3390/ijms160817763.
5
Energetic dysfunction in sepsis: a narrative review.脓毒症中的能量代谢功能障碍：一项叙述性综述
Ann Intensive Care. 2021 Jul 3;11(1):104. doi: 10.1186/s13613-021-00893-7.
6
A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome.脓毒症和多器官功能障碍综合征中线粒体功能障碍的实验治疗的系统评价。
Free Radic Biol Med. 2009 Dec 1;47(11):1517-25. doi: 10.1016/j.freeradbiomed.2009.08.019. Epub 2009 Aug 26.
7
Goodbye SIRS? Innate, trained and adaptive immunity and pathogenesis of organ dysfunction.“全身炎症反应综合征”不再存在？固有免疫、适应性免疫及器官功能障碍的发病机制
Med Klin Intensivmed Notfmed. 2020 May;115(Suppl 1):10-14. doi: 10.1007/s00063-020-00683-2. Epub 2020 Apr 14.
8
Better therapy for combat injury.更好的战斗伤害治疗方法。
Mil Med Res. 2019 Jul 25;6(1):23. doi: 10.1186/s40779-019-0214-9.
9
The emerging roles and therapeutic potential of B cells in sepsis.B细胞在脓毒症中的新作用及治疗潜力
Front Pharmacol. 2022 Nov 8;13:1034667. doi: 10.3389/fphar.2022.1034667. eCollection 2022.
10
Mitochondrial and endoplasmic reticulum dysfunction and related defense mechanisms in critical illness-induced multiple organ failure.危重病诱导的多器官衰竭中的线粒体和内质网功能障碍及相关防御机制。
Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt B):2534-2545. doi: 10.1016/j.bbadis.2017.02.015. Epub 2017 Feb 17.

引用本文的文献

1
Enhancing Mitochondrial Function Through Pharmacological Modification: A Novel Approach to Mitochondrial Transplantation in a Sepsis Model.通过药理学修饰增强线粒体功能：脓毒症模型中线粒体移植的新方法。
Biomedicines. 2025 Apr 10;13(4):934. doi: 10.3390/biomedicines13040934.
2
Sepsis and post-sepsis syndrome: a multisystem challenge requiring comprehensive care and management-a review.脓毒症和脓毒症后综合征：一项需要综合护理与管理的多系统挑战——综述
Front Med (Lausanne). 2025 Apr 8;12:1560737. doi: 10.3389/fmed.2025.1560737. eCollection 2025.
3
Stress Granules in Infectious Disease: Cellular Principles and Dynamic Roles in Immunity and Organelles.

本文引用的文献

1
Frontline Science: HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock.前沿科学：HMGB1在实验性脓毒症及脓毒性休克存活患者中诱导中性粒细胞功能障碍。
J Leukoc Biol. 2017 Jun;101(6):1281-1287. doi: 10.1189/jlb.5HI0316-128RR. Epub 2016 Dec 13.
2
Impact of Metformin Use on Lactate Kinetics in Patients with Severe Sepsis and Septic Shock.二甲双胍的使用对严重脓毒症和脓毒性休克患者乳酸动力学的影响。
Shock. 2017 May;47(5):582-587. doi: 10.1097/SHK.0000000000000782.
3
The immune system's role in sepsis progression, resolution, and long-term outcome.
传染病中的应激颗粒：细胞原理及其在免疫和细胞器中的动态作用
Int J Mol Sci. 2024 Dec 2;25(23):12950. doi: 10.3390/ijms252312950.
4
METABOLIC AND BIOENERGETIC ALTERATIONS ARE ASSOCIATED WITH INFECTION SUSCEPTIBILITY IN SURVIVORS OF SEVERE TRAUMA: AN EXPLORATORY STUDY.代谢和生物能量改变与严重创伤幸存者的感染易感性相关：一项探索性研究。
Shock. 2024 Nov 1;62(5):633-643. doi: 10.1097/SHK.0000000000002419. Epub 2024 Jul 16.
5
Unveiling the Role of Exosomes in the Pathophysiology of Sepsis: Insights into Organ Dysfunction and Potential Biomarkers.揭示外泌体在脓毒症病理生理学中的作用：对器官功能障碍的深入了解和潜在的生物标志物。
Int J Mol Sci. 2024 Apr 30;25(9):4898. doi: 10.3390/ijms25094898.
6
A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism.从代谢角度看中性粒细胞的生命周期：免疫代谢的新途径。
Front Immunol. 2024 Jan 8;14:1334205. doi: 10.3389/fimmu.2023.1334205. eCollection 2023.
7
Neutrophil extracellular trap formation and gene programs distinguish TST/IGRA sensitization outcomes among Mycobacterium tuberculosis exposed persons living with HIV.中性粒细胞胞外诱捕网形成和基因程序可区分 HIV 感染者中结核菌素皮肤试验/干扰素-γ释放试验致敏结果。
PLoS Genet. 2023 Aug 24;19(8):e1010888. doi: 10.1371/journal.pgen.1010888. eCollection 2023 Aug.
8
The importance of serum LMAN2 level in septic shock and prognosis prediction in sepsis patients.血清LMAN2水平在脓毒症休克及脓毒症患者预后预测中的重要性。
Heliyon. 2022 Nov 5;8(11):e11409. doi: 10.1016/j.heliyon.2022.e11409. eCollection 2022 Nov.
9
An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach.脓毒症相关性心肌功能障碍基于线粒体的治疗概述：线粒体移植作为一种有前景的方法
Can J Infect Dis Med Microbiol. 2022 Jun 6;2022:3277274. doi: 10.1155/2022/3277274. eCollection 2022.
10
Standardized fraction of Xylocarpus moluccensis inhibits inflammation by modulating MAPK-NFκB and ROS-HIF1α-PKM2 activation.标准化的毛桃木莲提取物通过调节 MAPK-NFκB 和 ROS-HIF1α-PKM2 的激活来抑制炎症。
Inflamm Res. 2022 Apr;71(4):423-437. doi: 10.1007/s00011-022-01549-3. Epub 2022 Mar 10.
免疫系统在脓毒症进展、缓解及长期预后中的作用。
Immunol Rev. 2016 Nov;274(1):330-353. doi: 10.1111/imr.12499.
4
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation.PKM2 依赖性糖酵解促进 NLRP3 和 AIM2 炎性小体激活。
Nat Commun. 2016 Oct 25;7:13280. doi: 10.1038/ncomms13280.
5
Absolute lactate value vs relative reduction as a predictor of mortality in severe sepsis and septic shock.在严重脓毒症和脓毒性休克中，绝对乳酸值与相对降低值作为死亡率预测指标的比较
J Crit Care. 2017 Feb;37:179-184. doi: 10.1016/j.jcrc.2016.09.023. Epub 2016 Oct 6.
6
Evolution of Blood Lactate and 90-Day Mortality in Septic Shock. A Post Hoc Analysis of the FINNAKI Study.脓毒症休克患者血乳酸水平变化与90天死亡率：FINNAKI研究的事后分析
Shock. 2017 May;47(5):574-581. doi: 10.1097/SHK.0000000000000772.
7
Frontline Science: D1 dopaminergic receptor signaling activates the AMPK-bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxin-induced ALI.前沿科学：D1多巴胺能受体信号激活巨噬细胞和肺泡上皮细胞中的AMPK-生物能量途径并减轻内毒素诱导的急性肺损伤。
J Leukoc Biol. 2017 Feb;101(2):357-365. doi: 10.1189/jlb.3HI0216-068RR. Epub 2016 Oct 12.
8
Cellular metabolism of myeloid cells in sepsis.脓毒症中髓系细胞的细胞代谢
J Leukoc Biol. 2017 Jan;101(1):151-164. doi: 10.1189/jlb.4MR0216-066R. Epub 2016 Jun 6.
9
Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis.脓毒症患者的代谢、代谢组学与营养支持
Clin Chest Med. 2016 Jun;37(2):321-31. doi: 10.1016/j.ccm.2016.01.011. Epub 2016 Mar 12.
10
Macrophages in Tissue Repair, Regeneration, and Fibrosis.组织修复、再生和纤维化中的巨噬细胞
Immunity. 2016 Mar 15;44(3):450-462. doi: 10.1016/j.immuni.2016.02.015.