Talbot Jessica J, Barrs Vanessa R
The University of Sydney, NSW 2006 Australia, Faculty of Veterinary Science, School of Life and Environmental Sciences.
Med Mycol. 2018 Jan 1;56(1):1-12. doi: 10.1093/mmy/myx016.
Cryptic species in Aspergillus section Fumigati are increasingly recognised as pathogens in humans and animals. The A. viridinutans complex (AVC) has recently expanded to comprise 10 species, of which six are known to be pathogenic, including A. udagawae, A. felis, A. pseudofelis, A. parafelis, A. pseudoviridinutans, and A. wyomingensis. They cause locally invasive and disseminated invasive disease syndromes, including chronic pulmonary aspergillosis and invasive aspergillosis in humans, invasive fungal rhinosinusitis in cats, and disseminated invasive aspergillosis in dogs. In contrast to A. fumigatus, AVC species are characterized by higher minimum inhibitory concentrations (MICs) of antifungal drugs and the infections they cause are typically more chronic and more refractory to therapy. This review, of relevance for one-health practitioners, explores the history of the AVC as well as current phylogenetic relationships, secondary metabolite production, environmental distribution, clinical syndromes, and antifungal susceptibility patterns.
烟曲霉属烟曲霉组中的隐秘种越来越被认为是人类和动物的病原体。绿褐曲霉复合体（AVC）最近已扩展到包括10个物种，其中已知6种具有致病性，包括宇田川曲霉、猫曲霉、假猫曲霉、副猫曲霉、假绿褐曲霉和怀俄明曲霉。它们会引起局部侵袭性和播散性侵袭性疾病综合征，包括人类的慢性肺曲霉病和侵袭性曲霉病、猫的侵袭性真菌性鼻鼻窦炎以及犬的播散性侵袭性曲霉病。与烟曲霉相比，AVC物种的特征是抗真菌药物的最低抑菌浓度（MIC）更高，并且它们引起的感染通常更具慢性且对治疗更具难治性。这篇对“同一健康”从业者具有参考价值的综述探讨了AVC的历史以及当前的系统发育关系、次生代谢产物产生、环境分布、临床综合征和抗真菌药敏模式。
