Padre-Mendoza T, Farnes P, Barker B E, Smith P S, Forman E N
Br J Haematol. 1979 Jan;41(1):43-8. doi: 10.1111/j.1365-2141.1979.tb03679.x.
During the past 3 1/2 years cytogenetic studies have been performed on all children with leukaemia prior to treatment. Loss of the Y chromosome documented by chromosome banding techniques, was observed in bone marrow blast cells from two of II consecutive male children. On patient had acute myeloblastic leukaemia of t(8;21) type. The other patient was diagnosed as acute lymphoblastic leukemia. Our studies provide evidence that Y loss occurs in childhood leukemias and is not necessarily related to an ageing process as suggested by others. Futhermore, this study demonstrates that Y loss can occur as a sole abnormality in non-myeloid leukaemia.
在过去3年半的时间里，对所有白血病患儿在治疗前都进行了细胞遗传学研究。通过染色体显带技术记录到，在11名连续的男性患儿的骨髓原始细胞中观察到Y染色体缺失。一名患者患有t(8;21)型急性髓细胞白血病。另一名患者被诊断为急性淋巴细胞白血病。我们的研究提供了证据，表明Y染色体缺失在儿童白血病中会出现，且不一定如其他人所认为的那样与衰老过程有关。此外，本研究表明Y染色体缺失在非髓细胞白血病中可能作为唯一的异常情况出现。
