一种区分儿童言语失用症与言语迟缓的诊断标志物：II. 停顿标志物的效度研究。
A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: II. Validity Studies of the Pause Marker.
作者信息
Shriberg Lawrence D, Strand Edythe A, Fourakis Marios, Jakielski Kathy J, Hall Sheryl D, Karlsson Heather B, Mabie Heather L, McSweeny Jane L, Tilkens Christie M, Wilson David L
机构信息
Waisman Center, University of Wisconsin-Madison.
Department of Neurology, Mayo Clinic, Rochester, MN.
出版信息
J Speech Lang Hear Res. 2017 Apr 14;60(4):S1118-S1134. doi: 10.1044/2016_JSLHR-S-15-0297.
PURPOSE
The purpose of this 2nd article in this supplement is to report validity support findings for the Pause Marker (PM), a proposed single-sign diagnostic marker of childhood apraxia of speech (CAS).
METHOD
PM scores and additional perceptual and acoustic measures were obtained from 296 participants in cohorts with idiopathic and neurogenetic CAS, adult-onset apraxia of speech and primary progressive apraxia of speech, and idiopathic speech delay.
RESULTS
Adjusted for questionable specificity disagreements with a pediatric Mayo Clinic diagnostic standard, the estimated sensitivity and specificity, respectively, of the PM were 86.8% and 100% for the CAS cohort, yielding positive and negative likelihood ratios of 56.45 (95% confidence interval [CI]: [1.15, 2763.31]) and 0.13 (95% CI [0.06, 0.30]). Specificity of the PM for 4 cohorts totaling 205 participants with speech delay was 98.5%.
CONCLUSION
These findings are interpreted as providing support for the PM as a near-conclusive diagnostic marker of CAS.
目的
本增刊中第二篇文章的目的是报告停顿标记（PM）的效度支持结果，PM是一种针对儿童言语失用症（CAS）提议的单信号诊断标记。
方法
从患有特发性和神经遗传性CAS、成人起病的言语失用症和原发性进行性言语失用症以及特发性言语延迟的队列中的296名参与者处获取PM分数以及其他感知和声学测量数据。
结果
针对与梅奥诊所儿科诊断标准存在可疑特异性分歧进行调整后，CAS队列中PM的估计敏感性和特异性分别为86.8%和100%，阳性似然比和阴性似然比分别为56.45（95%置信区间[CI]：[1.15, 2763.31]）和0.13（95%CI [0.06, 0.30]）。PM对总计205名有言语延迟参与者的4个队列的特异性为98.5%。
结论
这些结果被解释为支持PM作为CAS的近乎决定性诊断标记。
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