Ramakrishnan V, Akram Husain R S, Ahmed Shiek Ssj
Genetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, India.
Drug Discovery Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, India.
J Neuroimmunol. 2017 May 15;306:11-18. doi: 10.1016/j.jneuroim.2017.02.015. Epub 2017 Feb 22.
Interleukin-10 (IL-10) is a anti-inflammatory cytokine, which controls inflammation by inhibiting the synthesis of several cytokines produced by Th1 cells and macrophages. The association between Interleukin-10 promoter polymorphisms with the risk of multiple sclerosis (MS) remains inconclusive. In this study, a meta-analysis has been performed to assess the relationship between IL-10 gene polymorphisms rs1800896, rs1800871 and rs1800872 with the risk of MS. Nine case-control studies were selected involving 2755 participants. The association between the polymorphisms and MS was examined by the pooled odds ratios (ORs) with 95% confidence intervals (CIs) in allelic, homozygote, heterozygote, dominant and recessive genetic models. Of analyzed genetic models, the pooled ORs and CIs of each SNPs calculated based on random (I>50) or fixed effects (I<50) methods, which showed no significant association (p-value>0.05) of genetic predisposition with MS susceptibility across Asian and Caucasian populations. In addition, assessment based on funnel plot and Egger's linear regression test suggests no publication bias in all analyzed genetic models. Overall, our results demonstrated that rs1800896, rs1800871 and rs1800872 polymorphisms may not be the risk factor for the development of MS in both the populations.
白细胞介素-10（IL-10）是一种抗炎细胞因子，它通过抑制Th1细胞和巨噬细胞产生的几种细胞因子的合成来控制炎症。白细胞介素-10启动子多态性与多发性硬化症（MS）风险之间的关联尚无定论。在本研究中，进行了一项荟萃分析，以评估IL-10基因多态性rs1800896、rs1800871和rs1800872与MS风险之间的关系。选择了9项病例对照研究，涉及2755名参与者。通过等位基因、纯合子、杂合子、显性和隐性遗传模型中的合并比值比（OR）及95%置信区间（CI）来检验多态性与MS之间的关联。在分析的遗传模型中，基于随机（I>50）或固定效应（I<50）方法计算每个单核苷酸多态性（SNP）的合并OR和CI，结果显示在亚洲和白种人群中，遗传易感性与MS易感性之间无显著关联（p值>0.05）。此外，基于漏斗图和Egger线性回归检验的评估表明，在所有分析的遗传模型中均无发表偏倚。总体而言，我们的结果表明，rs1800896、rs1800871和rs1800872多态性可能不是这两个人群中MS发病的危险因素。
