通过脊髓神经调节使截瘫患者实现特定任务的自主运动功能。
Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia.
作者信息
Grahn Peter J, Lavrov Igor A, Sayenko Dimitry G, Van Straaten Meegan G, Gill Megan L, Strommen Jeffrey A, Calvert Jonathan S, Drubach Dina I, Beck Lisa A, Linde Margaux B, Thoreson Andrew R, Lopez Cesar, Mendez Aldo A, Gad Parag N, Gerasimenko Yury P, Edgerton V Reggie, Zhao Kristin D, Lee Kendall H
机构信息
Department of Neurologic Surgery, Mayo Clinic, Rochester, MN.
Department of Integrative Biology and Physiology, University of California Los Angeles.
出版信息
Mayo Clin Proc. 2017 Apr;92(4):544-554. doi: 10.1016/j.mayocp.2017.02.014.
We report a case of chronic traumatic paraplegia in which epidural electrical stimulation (EES) of the lumbosacral spinal cord enabled (1) volitional control of task-specific muscle activity, (2) volitional control of rhythmic muscle activity to produce steplike movements while side-lying, (3) independent standing, and (4) while in a vertical position with body weight partially supported, voluntary control of steplike movements and rhythmic muscle activity. This is the first time that the application of EES enabled all of these tasks in the same patient within the first 2 weeks (8 stimulation sessions total) of EES therapy.
我们报告了一例慢性创伤性截瘫病例，其中对腰骶脊髓进行硬膜外电刺激（EES）实现了：（1）对特定任务肌肉活动的自主控制；（2）对有节奏肌肉活动的自主控制，以便在侧躺时产生类似踏步的动作；（3）独立站立；（4）在部分体重得到支撑的垂直姿势下，自主控制类似踏步的动作和有节奏的肌肉活动。这是首次在EES治疗的前2周（总共8次刺激疗程）内，EES的应用使同一患者完成了所有这些任务。
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