University of Maribor, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor, Slovenia.
University of Maribor, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor, Slovenia; University of Tirana, Faculty of Natural Sciences, Boulevard "Zogu I", 1001 Tirana, Albania.
Carbohydr Polym. 2017 Jun 15;166:365-376. doi: 10.1016/j.carbpol.2017.03.008. Epub 2017 Mar 7.
In this study, we developed a novel high methoxyl pectin-xanthan aerogel coating on medical-grade stainless steel, prepared by ethanol-induced gelation and subsequent supercritical drying. Two non-steroidal anti-inflammatory drugs, i.e. diclofenac sodium and indomethacin, were incorporated into the aerogel coating. Electrochemical analyses were performed on the coated samples using electrochemical impedance spectroscopy and cyclic polarization techniques. The results showed that all passivated samples were highly resistant to general corrosion. The release of both non-steroidal anti-inflammatory drugs was complete after 24h, as confirmed by the plateau in the drug release profiles as well as by IR spectroscopy after the final release point. The potential of samples for use in orthopedic applications was evaluated on a human bone-derived osteoblast cell and all samples were shown to be biocompatible. The increased viability of some samples indicates the high potential of the developed approach for future evaluation of possible clinical use.
本研究开发了一种新型的基于高甲氧基果胶-黄原胶的医用级不锈钢气凝胶涂层，采用乙醇诱导凝胶化和随后的超临界干燥制备而成。两种非甾体抗炎药，即双氯芬酸钠和吲哚美辛，被掺入气凝胶涂层中。使用电化学阻抗谱和循环极化技术对涂层样品进行了电化学分析。结果表明，所有钝化样品均具有高度的抗整体腐蚀能力。通过药物释放曲线的平台以及最后释放点后的 IR 光谱，证实了两种非甾体抗炎药在 24 小时内完全释放。通过对来源于人骨的成骨细胞的评估，研究了样品在骨科应用中的潜力，所有样品均表现出良好的生物相容性。一些样品的细胞活力增加表明，所开发方法具有很高的潜在应用价值，可用于未来的临床应用评估。
