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白藜芦醇通过小鼠和大鼠经典模型的镇痛和抗炎活性

Analgesic and Anti-Inflammatory Activities of Resveratrol through Classic Models in Mice and Rats.

作者信息

Wang Guangxi, Hu Zhiqiang, Song Xu, Cui Qiankun, Fu Qiuting, Jia Renyong, Zou Yuanfeng, Li Lixia, Yin Zhongqiong

机构信息

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.

Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.

出版信息

Evid Based Complement Alternat Med. 2017;2017:5197567. doi: 10.1155/2017/5197567. Epub 2017 Mar 13.

DOI:10.1155/2017/5197567
PMID:28386290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5366799/
Abstract

. Inflammation and pain are closely related to humans' and animals' health. (RSV) is a natural compound with various biological activities. The current study is aimed to evaluate the analgesic and anti-inflammatory activities of RSV in vivo. The analgesic effects were assessed by the acetic acid-induced writhing and hot plate tests. The anti-inflammatory effects were determined using the xylene-induced mouse ear oedema, the acetic acid-induced rat pleurisy, and carrageenan-induced rat synovitis tests, respectively. . The analgesic results showed that RSV could significantly inhibit the number of writhes and improve the time and pain threshold of mice standing on hot plate. The anti-inflammatory results showed that RSV could inhibit the ear oedema of mice. In acetic acid-induced pleurisy test, RSV could significantly inhibit the WBC and pleurisy exudates, could decrease the production of NO, and elevate the activity of SOD in serum. In carrageenan-induced synovitis test, RSV could reduce the content of MDA and elevate the T-SOD activity in serum; RSV could inhibit the expressions of TP, PGE2, NO, and MDA. . Shortly, these results indicated that RSV had potent analgesic and anti-inflammatory activities and could be a potential new drug candidate for the treatment of inflammation and pain.

摘要

炎症和疼痛与人类及动物的健康密切相关。白藜芦醇（RSV）是一种具有多种生物活性的天然化合物。当前研究旨在评估RSV在体内的镇痛和抗炎活性。通过醋酸诱导扭体试验和热板试验评估镇痛效果。分别使用二甲苯诱导的小鼠耳肿胀、醋酸诱导的大鼠胸膜炎和角叉菜胶诱导的大鼠滑膜炎试验来测定抗炎效果。镇痛结果表明，RSV可显著抑制扭体次数，并提高小鼠在热板上站立的时间和疼痛阈值。抗炎结果表明，RSV可抑制小鼠耳肿胀。在醋酸诱导的胸膜炎试验中，RSV可显著抑制白细胞和胸膜炎渗出物，可降低一氧化氮（NO）的产生，并提高血清中超氧化物歧化酶（SOD）的活性。在角叉菜胶诱导的滑膜炎试验中，RSV可降低血清中丙二醛（MDA）的含量并提高总超氧化物歧化酶（T-SOD）的活性；RSV可抑制血栓素（TP）、前列腺素E2（PGE2）、NO和MDA的表达。简而言之，这些结果表明RSV具有强大的镇痛和抗炎活性，可能是治疗炎症和疼痛的潜在新药候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/a1392956d4a2/ECAM2017-5197567.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/feeecbc51696/ECAM2017-5197567.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/306519ff70cc/ECAM2017-5197567.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/85c71df6f8aa/ECAM2017-5197567.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/45654c123e90/ECAM2017-5197567.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/a1392956d4a2/ECAM2017-5197567.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/feeecbc51696/ECAM2017-5197567.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/306519ff70cc/ECAM2017-5197567.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/85c71df6f8aa/ECAM2017-5197567.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/45654c123e90/ECAM2017-5197567.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/248c/5366799/a1392956d4a2/ECAM2017-5197567.005.jpg

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