Montero Juan A, Lorda-Diez Carlos I, Francisco-Morcillo Javier, Chimal-Monroy Jesus, Garcia-Porrero Juan A, Hurle Juan M
Departamento de Anatomía y Biología Celular and IDIVAL, Universidad de Cantabria Santander, Spain.
Departamento de Anatomía, Biología Celular, y Zoología, Universidad de Extremadura Badajoz, Spain.
Front Cell Dev Biol. 2017 Mar 23;5:23. doi: 10.3389/fcell.2017.00023. eCollection 2017.
In tetrapods the digit pattern has evolved to adapt to distinct locomotive strategies. The number of digits varies between species or even between hindlimb and forelimb within the same species. These facts illustrate the plasticity of embryonic limb autopods. is a precocious marker of skeletal differentiation of limb mesenchymal cells. Its pattern of expression in the developing limb has been widely studied and reflects the activity of signaling cascades responsible for skeletogenesis. In this assay we stress previously overlooked differences in the pattern of expression of Sox9 in limbs of avian, mouse and turtle embryos which may reflect signaling differences associated with distinct limb skeletal morphologies observed in these species. Furthermore, we show that gene expression is higher and maintained in the interdigital region in species with webbed digits in comparison with free digit animals.
在四足动物中，指（趾）模式已经进化以适应不同的运动策略。指（趾）的数量在不同物种之间甚至在同一物种的后肢和前肢之间都有所不同。这些事实说明了胚胎肢体自主体节的可塑性。[此处原文缺失具体内容，无法准确翻译]是肢体间充质细胞骨骼分化的早熟标志物。其在发育中的肢体中的表达模式已得到广泛研究，并反映了负责骨骼形成的信号级联的活性。在本实验中，我们强调了之前被忽视的鸡、小鼠和龟胚胎肢体中Sox9表达模式的差异，这些差异可能反映了与这些物种中观察到的不同肢体骨骼形态相关的信号差异。此外，我们表明，与具有游离指（趾）的动物相比，在具有蹼指（趾）的物种中，[此处原文缺失具体基因名称，无法准确翻译]基因表达在指间区域更高且持续存在。
