真菌生物膜：从内到外。
Fungal Biofilms: Inside Out.
机构信息
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
出版信息
Microbiol Spectr. 2017 Apr;5(2). doi: 10.1128/microbiolspec.FUNK-0024-2016.
Abstract
We focus this article on turning a biofilm inside out. The "inside" of the biofilm comprises the individual biofilm-related phenotypes, their environmental drivers and genetic determinants, and the coordination of gene functions through transcriptional regulators. Investigators have viewed the inside of the biofilm through diverse approaches, and this article will attempt to capture the essence of many. The ultimate goal is to connect the inside to the "outside," which we view as biofilm structure, development, pharmacological attributes, and medical impact.
摘要
本文聚焦于使生物膜“翻面”。生物膜的“内面”包含单个生物膜相关表型、其环境驱动力和遗传决定因素，以及通过转录调节剂协调基因功能。研究人员通过多种方法观察生物膜的内部，本文将尝试捕捉其中的许多要点。最终目标是将内部与“外部”联系起来，我们将生物膜的外部视为生物膜的结构、发展、药理学特性和医学影响。
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本文引用的文献
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Targeting Fibronectin To Disrupt In Vivo Candida albicans Biofilms.靶向纤连蛋白以破坏体内白色念珠菌生物膜
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