Mintz U, Vardiman J, Golomb H M, Rowley J D
Cancer. 1979 Feb;43(2):411-6. doi: 10.1002/1097-0142(197902)43:2<411::aid-cncr2820430202>3.0.co;2-2.
Ten of 55 patients with chronic myelogenous leukemia (CML) diagnosed between 1972 and 1977 were found to lack the Philadelphia (Ph1) chromosome. Serial clinical, morphologic, and cytogenetic studies of patients with Ph1-negative CML showed that 30% of them had chromosomal abnormalities. Two had an extra chromosome No. 8 at the time of blast crisis, with a morphological picture of myeloblasts in the bone marrow. A third patient had a 6:14 translocation initially Abnormalities of chromosome No. 14 are frequently seen in lymphoproliferative disorders, and the bone marrow and peripheral blood contained a significant population of lymphoblasts as well as myeloblasts. The median survival for the 10 patients was 19 months. The exact nature of Ph1-negative CML is not yet clear; disease appears to be a distinct entity among the myeloproliferative disorders.
在1972年至1977年间被诊断为慢性粒细胞白血病（CML）的55例患者中，有10例被发现缺乏费城（Ph1）染色体。对Ph1阴性CML患者进行的系列临床、形态学和细胞遗传学研究表明，其中30%存在染色体异常。两名患者在急变期出现额外的8号染色体，骨髓中有成髓细胞的形态学表现。第三名患者最初有6:14易位。14号染色体异常在淋巴增殖性疾病中常见，该患者的骨髓和外周血中既有大量的成淋巴细胞，也有成髓细胞。这10例患者的中位生存期为19个月。Ph1阴性CML的确切性质尚不清楚；该疾病似乎是骨髓增殖性疾病中的一个独特实体。
