Noguchi T, Sugisaki T, Tsukada Y
J Neurochem. 1982 Jan;38(1):257-63. doi: 10.1111/j.1471-4159.1982.tb10878.x.
Snell dwarf mice (dw) showed a lower CNPase activity (59% of the normal controls) only in the cerebrum among different parts of the CNS, and a strikingly reduced level of spontaneous locomotion activity with an indistinct diurnal periodicity in a 24-h record at 40 days of age. Daily administration of bGH and T4 to the dwarfs during the first 40 days of postnatal life restored CNPase activity to the level of the normal controls, and was accompanied by normalization of the pattern of spontaneous locomotion activity. Daily administration of bGH alone also restored CNPase activity and spontaneous locomotion, but to a lesser extent. The daily administration of thyroid stimulating hormone (TSH) alone, however, failed to restore CNPase activity, in spite of the fact that the thyroid glands of the TSH-treated dwarfs were indistinguishable from the normal controls in organization and appearance. These results indicate that the restoration of both the retarded myelinogenesis and abnormal behavior of the Snell dwarf mice might essentially depend upon GH levels and the synergistic effects of T4.
斯内尔侏儒小鼠（dw）仅在中枢神经系统不同部位的大脑中显示出较低的CNPase活性（为正常对照的59%），并且在40日龄时，其自发运动活动水平显著降低，在24小时记录中昼夜节律不明显。在出生后的前40天，每天给侏儒小鼠注射bGH和T4，可使CNPase活性恢复到正常对照水平，并伴随着自发运动活动模式的正常化。单独每天注射bGH也能恢复CNPase活性和自发运动，但程度较小。然而，尽管接受促甲状腺激素（TSH）治疗的侏儒小鼠的甲状腺在组织结构和外观上与正常对照无明显差异，但单独每天注射TSH未能恢复CNPase活性。这些结果表明，斯内尔侏儒小鼠延迟的髓鞘形成和异常行为的恢复可能本质上取决于生长激素水平以及T4的协同作用。
