Sirakova I, Panova D, Georgiev P, Sirakov L M
Department of Biochemistry, Medical Academy, Sofia, Bulgaria.
Pavlov J Biol Sci. 1988 Apr-Jun;23(2):54-6. doi: 10.1007/BF02995655.
Two types of opioid receptors were studied in the brain of rats: Delta (for endogenous opiate) and mu (for exogenous opiates). 3H derivates: D-Ala2-enkephalin and Naloxone were used as labeled ligands. The results obtained were calculated by computer program for automatic estimation of the data using approximation equations. An increase of binding delta receptors is observed in both types of stress (2-8 times), while to the mu receptors the binding is less effective mainly after irradiation. These data suggest that a close interaction exists between sympathoadrenal system and opioid mechanisms during stress.
δ受体（针对内源性阿片）和μ受体（针对外源性阿片）。使用了3H衍生物：D-丙氨酸2-脑啡肽和纳洛酮作为标记配体。通过计算机程序使用近似方程对获得的结果进行自动数据估计计算。在两种应激类型中均观察到δ受体结合增加（2至8倍），而对于μ受体，主要在照射后结合效果较差。这些数据表明，应激期间交感肾上腺系统与阿片机制之间存在密切相互作用。
