Sayanagi Kaori, Ikuno Yasushi, Uematsu Sato, Nishida Kohji
Department of Ophthalmology, Osaka University Medical School, Osaka, Japan.
Br J Ophthalmol. 2017 Nov;101(11):1524-1529. doi: 10.1136/bjophthalmol-2016-309628. Epub 2017 Mar 17.
To describe the choriocapillaris features imaged by optical coherence tomography angiography (OCTA) in eyes with myopic maculopathy.
In this retrospective, non-invasive, observational case series, 26 eyes with myopic maculopathy and 12 age-matched healthy eyes underwent fluorescein angiography, indocyanine green angiography (ICGA) (highly myopic eyes only), OCT and OCTA, and the choriocapillaris features seen on OCTA and ICGA were compared.
In all five (19%) eyes with patchy atrophy of the 26 highly myopic eyes, OCTA showed complete loss of the choriocapillaris and large choroidal vessels in the atrophic area. In nine (35%) eyes with diffuse atrophy in the atrophic area, OCTA showed low-density choriocapillaris in all eyes and medium and large choroidal vessels in seven (78%) eyes. In 23 eyes (88%) with lacquer cracks, OCTA showed partial loss of the choriocapillaris in 22 (96%) eyes in the area of the lacquer cracks. OCTA could not visualise the full length of the lacquer cracks in any eyes compared with ICGA.
OCTA visualised the choriocapillaris clearly. The choriocapillaris features differed depending to the category of myopic maculopathy. In eyes with lacquer cracks, choriocapillaris rupture might be less advanced than the breaks in Bruch's membrane and retinal pigment epithelium.
描述光学相干断层扫描血管造影（OCTA）成像的高度近视性黄斑病变眼中脉络膜毛细血管的特征。
在这个回顾性、非侵入性、观察性病例系列中，26只高度近视性黄斑病变眼和12只年龄匹配的健康眼接受了荧光素血管造影、吲哚菁绿血管造影（仅高度近视眼）、OCT和OCTA检查，并比较了OCTA和吲哚菁绿血管造影所见的脉络膜毛细血管特征。
在26只高度近视眼中，所有5只（19%）有片状萎缩的眼中，OCTA显示萎缩区域的脉络膜毛细血管和大脉络膜血管完全缺失。在萎缩区域有弥漫性萎缩的9只（35%）眼中，OCTA显示所有眼中脉络膜毛细血管密度低，7只（78%）眼中有中、大脉络膜血管。在23只（88%）有漆裂纹的眼中，OCTA显示22只（96%）眼在漆裂纹区域脉络膜毛细血管部分缺失。与吲哚菁绿血管造影相比，OCTA在任何眼中均无法显示漆裂纹的全长。
OCTA能清晰显示脉络膜毛细血管。脉络膜毛细血管特征因高度近视性黄斑病变类型而异。在有漆裂纹的眼中，脉络膜毛细血管破裂可能比布鲁赫膜和视网膜色素上皮的破裂进展程度轻。
