Krautkramer Kimberly A, Rey Federico E, Denu John M
From the Wisconsin Institute for Discovery, Morgridge Institute for Research, and the Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53715 and.
the Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53706
J Biol Chem. 2017 May 26;292(21):8582-8593. doi: 10.1074/jbc.R116.761577. Epub 2017 Apr 7.
Mammals and their gut microbial communities share extensive and tightly coordinated co-metabolism of dietary substrates. A large number of microbial metabolites have been detected in host circulation and tissues and, in many cases, are linked to host metabolic, developmental, and immunological states. The presence of these metabolites in host tissues intersects with regulation of the host's epigenetic machinery. Although it is established that the host's epigenetic machinery is sensitive to levels of endogenous metabolites, the roles for microbial metabolites in epigenetic regulation are just beginning to be elucidated. This review focuses on eukaryotic chromatin regulation by endogenous and gut microbial metabolites and how these regulatory events may impact host developmental and metabolic phenotypes.
哺乳动物及其肠道微生物群落对膳食底物具有广泛且紧密协调的共同代谢。在宿主循环系统和组织中已检测到大量微生物代谢产物，并且在许多情况下，这些代谢产物与宿主的代谢、发育和免疫状态相关。这些代谢产物在宿主组织中的存在与宿主表观遗传机制的调节相互作用。虽然已经确定宿主的表观遗传机制对内源代谢产物水平敏感，但微生物代谢产物在表观遗传调节中的作用才刚刚开始得到阐明。本综述重点关注内源性和肠道微生物代谢产物对真核染色质的调节作用，以及这些调节事件如何影响宿主的发育和代谢表型。
