Kolli Udhghatri, Roy Sabita
Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, United States.
Front Microbiol. 2023 Aug 21;14:1233194. doi: 10.3389/fmicb.2023.1233194. eCollection 2023.
The current opioid pandemic is a major public health crisis in the United States, affecting millions of people and imposing significant health and socioeconomic burdens. Preclinical and clinical research over the past few decades has delineated certain molecular mechanisms and identified various genetic, epigenetic, and environmental factors responsible for the pathophysiology and comorbidities associated with opioid use. Opioid use-induced epigenetic modifications have been identified as one of the important factors that mediate genetic changes in brain regions that control reward and drug-seeking behavior and are also implicated in the development of tolerance. Recently, it has been shown that opioid use results in microbial dysbiosis, leading to gut barrier disruption, which drives systemic inflammation, impacting the perception of pain, the development of analgesic tolerance, and behavioral outcomes. In this review, we highlight the potential role of microbiota and microbial metabolites in mediating the epigenetic modifications induced by opioid use.
当前的阿片类药物流行是美国的一个重大公共卫生危机，影响着数百万人，并带来了巨大的健康和社会经济负担。在过去几十年中，临床前和临床研究已经阐明了某些分子机制，并确定了导致与阿片类药物使用相关的病理生理学和合并症的各种遗传、表观遗传和环境因素。阿片类药物使用引起的表观遗传修饰已被确定为介导控制奖励和觅药行为的脑区遗传变化的重要因素之一，并且也与耐受性的发展有关。最近，研究表明阿片类药物使用会导致微生物群落失调，从而导致肠道屏障破坏，进而引发全身炎症，影响疼痛感知、镇痛耐受性的发展以及行为结果。在这篇综述中，我们强调了微生物群和微生物代谢产物在介导阿片类药物使用引起的表观遗传修饰中的潜在作用。
