Horn Andreas, Neumann Wolf-Julian, Degen Katharina, Schneider Gerd-Helge, Kühn Andrea A
Department of Neurology, Movement Disorders and Neuromodulation Unit, Charité - University Medicine, Berlin, D-10117, Germany.
Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Hum Brain Mapp. 2017 Jul;38(7):3377-3390. doi: 10.1002/hbm.23594. Epub 2017 Apr 8.
Enhanced beta-band activity recorded in patients suffering from Parkinson's Disease (PD) has been described as a potential physiomarker for disease severity. Beta power is suppressed by Levodopa intake and STN deep brain stimulation (DBS) and correlates with disease severity across patients. The aim of the present study was to explore the promising signature of the physiomarker in the spatial domain. Based on local field potential data acquired from 54 patients undergoing STN-DBS, power values within alpha, beta, low beta, and high beta bands were calculated. Values were projected into common stereotactic space after DBS lead localization. Recorded beta power values were significantly higher at posterior and dorsal lead positions, as well as in active compared with inactive pairs. The peak of activity in the beta band was situated within the sensorimotor functional zone of the nucleus. In contrast, higher alpha activity was found in a more ventromedial region, potentially corresponding to associative or premotor functional zones of the STN. Beta- and alpha-power peaks were then used as seeds in a fiber tracking experiment. Here, the beta-site received more input from primary motor cortex whereas the alpha-site was more strongly connected to premotor and prefrontal areas. The results summarize predominant spatial locations of frequency signatures recorded in STN-DBS patients in a probabilistic fashion. The site of predominant beta-activity may serve as an electrophysiologically determined target for optimal outcome in STN-DBS for PD in the future. Hum Brain Mapp 38:3377-3390, 2017. © 2017 Wiley Periodicals, Inc.
帕金森病（PD）患者记录到的增强β波段活动已被描述为疾病严重程度的潜在生理标志物。左旋多巴摄入和丘脑底核深部脑刺激（DBS）可抑制β功率，且在患者中β功率与疾病严重程度相关。本研究的目的是在空间域中探索这种生理标志物的有前景的特征。基于从54名接受丘脑底核深部脑刺激的患者获取的局部场电位数据，计算了α、β、低β和高β波段内的功率值。在DBS电极定位后，将这些值投影到共同的立体定向空间中。记录到的β功率值在电极的后位和背位显著更高，并且与非激活对相比在激活对中也更高。β波段的活动峰值位于核的感觉运动功能区内。相比之下，在更腹内侧区域发现了更高的α活动，这可能对应于丘脑底核的联合或运动前功能区。然后将β和α功率峰值用作纤维追踪实验的种子点。在此，β位点从初级运动皮层接收更多输入，而α位点与运动前和前额叶区域的连接更强。结果以概率方式总结了丘脑底核深部脑刺激患者记录到的频率特征的主要空间位置。主要β活动的位点可能在未来成为丘脑底核深部脑刺激治疗帕金森病实现最佳结果的电生理确定靶点。《人类大脑图谱》38:3377 - 3390，2017年。© 2017威利期刊公司
