Guan-Yu Zhu, Zi-Xiao Yin, Ying-Chuan Chen, Merk Timon, Binns Thomas, Ruo-Yu Ma, Ting-Ting Du, Yu-Ye Liu, Hu-Tao Xie, Lin Shi, An-Chao Yang, Fan-Gang Meng, Neumann Wolf-Julian, Kühn Andrea A, Jian-Guo Zhang
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin, Berlin, Germany.
Ann Clin Transl Neurol. 2025 May;12(5):1082-1092. doi: 10.1002/acn3.70040. Epub 2025 Apr 3.
Deep brain stimulation offers a unique opportunity to record neural activity of the basal ganglia. While much work in dystonia has focused on the globus pallidus internus, expanding research to investigate subthalamic nucleus (STN) activity in various dystonia types is critical to provide a comprehensive understanding of dystonia pathophysiology.
STN and cortex activity were recorded from 17 patients with cervical dystonia (CD), 19 with Meige syndrome, and 9 with generalized dystonia (GD) during the lead externalized period. We investigated local and network oscillatory characteristics, including power, bursts, and coherence. Additionally, we explored the relationship between these features and the severity of dystonic symptoms within each group and conducted a comparative analysis across the different dystonia types.
Peaks of low-frequency (4-13 Hz) and beta (14-30 Hz) power were present in the STN of all patients; most of the beta peaks are distributed in the high beta range (20-30 Hz). The CD and GD groups showed longer low-frequency bursts and greater high beta power in STN than the Meige group. Interestingly, the CD group showed stronger STN-cortex low-frequency coherence, while the GD group had stronger STN-cortex high beta coherence. Combined, low-frequency and beta features could predict symptom severity with a performance of 73% in the CD group and 82% in the GD group.
Low-frequency and high-beta oscillations are present in the STN across all three types of dystonia. The distinct patterns may be associated with different underlying pathological mechanisms.
深部脑刺激为记录基底神经节的神经活动提供了独特的机会。虽然在肌张力障碍方面的许多工作都集中在内侧苍白球，但扩大研究以调查不同类型肌张力障碍中丘脑底核（STN）的活动对于全面理解肌张力障碍的病理生理学至关重要。
在电极外置期间，记录了17例颈部肌张力障碍（CD）患者、19例Meige综合征患者和9例全身性肌张力障碍（GD）患者的STN和皮层活动。我们研究了局部和网络振荡特征，包括功率、爆发和相干性。此外，我们探讨了每组中这些特征与肌张力障碍症状严重程度之间的关系，并对不同类型的肌张力障碍进行了比较分析。
所有患者的STN中均存在低频（4 - 13Hz）和β（14 - 30Hz）功率峰值；大多数β峰值分布在高β范围（20 - 30Hz）。与Meige组相比，CD组和GD组在STN中显示出更长的低频爆发和更高的高β功率。有趣的是，CD组显示出更强的STN - 皮层低频相干性，而GD组具有更强的STN - 皮层高β相干性。综合来看，低频和β特征能够预测症状严重程度，在CD组中的预测性能为73%，在GD组中为82%。
在所有三种类型的肌张力障碍中，STN均存在低频和高β振荡。这些不同的模式可能与不同的潜在病理机制相关。
