患者尾状核灰质体积减少与持续性阴性症状：一项基于激活似然估计的荟萃分析。
Grey matter reduction in the caudate nucleus in patients with persistent negative symptoms: An ALE meta-analysis.
机构信息
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Haidian District Mental Health Prevent-Treatment Hospital, Beijing, China.
Haidian District Mental Health Prevent-Treatment Hospital, Beijing, China.
出版信息
Schizophr Res. 2018 Feb;192:9-15. doi: 10.1016/j.schres.2017.04.005. Epub 2017 Apr 5.
OBJECTIVES
In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS).
METHOD
A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more stringent criterion of PNS.
RESULTS
Significant grey matter reduction in the PNS group relative to controls was observed in the left caudate nucleus, the left precentral region, the left middle frontal region, the bilateral parahippocampal region, the left anterior cingulate region, the bilateral medial frontal gyrus, the thalamus and the insula.
CONCLUSION
Our results suggest that brain regions in the reward network may be specifically related to PNS, especially the left caudate nucleus. It is possible that abnormality in reward processing may constitute the neural basis of PNS.
目的
本研究采用激活似然估计（ALE）荟萃分析，定量研究伴有持续性阴性症状（PNS）的精神分裂症患者的脑灰质减少。
方法
采用更严格的 PNS 标准，共纳入 12 项基于体素的形态测量学（VBM）研究进行 ALE 荟萃分析。
结果
与对照组相比，PNS 组左侧尾状核、左侧中央前回、左侧额中回、双侧海马旁回、左侧扣带回前部、双侧额内回、丘脑和岛叶灰质明显减少。
结论
我们的研究结果表明，奖励网络中的脑区可能与 PNS 特别是左侧尾状核有特定的关系。异常的奖励处理可能构成 PNS 的神经基础。
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