Fera Science Ltd., Sand Hutton, York, YO41 1LZ, UK.
Fera Science Ltd., Sand Hutton, York, YO41 1LZ, UK.
Environ Int. 2017 Jul;104:1-13. doi: 10.1016/j.envint.2017.02.015. Epub 2017 Apr 7.
Polychlorinated naphthalenes (PCNs) are legacy contaminants that are listed by the Stockholm convention, initially for reduction of inadvertent production and ultimately, for elimination. They originate through releases from older electrical equipment, inadvertent contamination in industrial chemicals and from combustion processes such as incineration. Recent advances in measurement techniques have allowed a greater characterisation of PCN occurrence, yielding more specific data including individual PCN congener concentrations. Emerging data on food shows widespread occurrence in most commonly consumed foods from different parts of the world. Concurrently, toxicological studies have also allowed a greater insight into the potencies of some congeners, a number of which are known to elicit potent, aryl hydrocarbon receptor (AhR) mediated responses, often referred to as dioxin-like toxicity. The dietary pathway is widely recognised as the most likely route to non-occupational human exposure. This paper reviews some of the more recent findings on PCN occurrence in food, biota, and human tissues, and discusses the use of relative potencies to express PCN toxicity in foods.
多氯萘（PCNs）是斯德哥尔摩公约列出的一种传统污染物，最初是为了减少无意生产，最终是为了消除。它们来源于旧电器设备的排放、工业化学品的无意污染以及焚烧等燃烧过程。测量技术的最新进展使得对 PCN 出现的特征描述更加准确，提供了更具体的数据，包括个别 PCN 同系物的浓度。关于食品的新兴数据表明，在世界不同地区最常食用的食品中普遍存在。与此同时，毒理学研究也使人们对某些同系物的效力有了更深入的了解，其中一些被认为能引发强烈的、芳香烃受体（AhR）介导的反应，通常被称为类二恶英毒性。饮食途径被广泛认为是人类非职业暴露的最可能途径。本文综述了食品、生物群和人体组织中 PCN 存在的一些最新发现，并讨论了在食品中表达 PCN 毒性时使用相对效力的问题。
