Jacob Stephan, Klimke-Hübner Andrea, Dippel Franz-Werner, Hopfenmüller Werner
Cardiometabolic Institute, Villingen-Schwenningen.
Diabetes Communications, Sanofi Deutschland GmbH, Frankfurt.
Cardiovasc Endocrinol. 2016 Mar;5(1):14-20. doi: 10.1097/XCE.0000000000000072. Epub 2016 Jan 4.
During the 'Knowing what matters in diabetes: healthier below 7' diabetes campaign, more than 30 000 randomly participating individuals underwent an occasional, voluntary diabetes risk check between 2005 and 2014.
This campaign aimed to inform individuals in Germany about diabetes mellitus and its complications, the established risk factors for development of type 2 diabetes (T2D), their prevalence and management in the real-life population, the quality of risk factor control and actual disease management in participants with a history of established diabetes mellitus [people with diabetes (PWD)]. Besides demographic characteristics (e.g. sex, age) and anamnestic information (antihypertensive treatment, history of elevated plasma glucose levels, genetic disposition), risk factor assessment included BMI, waist circumference, and lifestyle (physical activity, nutritional habits). The requested information was complemented by direct measurements of blood pressure (BP) (routine), plasma glucose, and HbA (voluntary). Between 2005 and 2014, more than 31 000 individuals participated in 45 single campaigns in numerous German cities. Here, we report on the results of the subgroup of participants with known diabetes mellitus.
Among the 26 522 individuals with a completed questionnaire participating in the years 2006-2014, 21 055 participants (79.4%) did not have a history of diabetes and 5098 individuals (19.2%) reported being diagnosed with T2D, 369 (1.4%) with type 1 diabetes. The proportion of participants with T2D increased markedly over the years from 13.3 (2006) to 21.7% (2014). The age group older than 64 years was the largest within this subgroup (67.3%), 48.4% men and 51.6% women. The prevalence of overweight or obesity was found in 78% and 69.2% of the PWD. More than 40% of individuals with T2D had no regular physical exercise and more than 15% had unfavorable nutritional habits. In all, 69.9% of participants with T2D had elevated BP as assessed during the campaign or reported treatment with antihypertensive drugs at any time. On average, almost half of PWD (46.3%) had an HbA above 7.0%; a significant trend toward higher values over the 10-year period was observed.
The analysis of PWD participating in the 'Knowing what matters in diabetes: healthier below 7' campaign showed that despite huge efforts in the past, important aspects for progression and complications of T2D mellitus are still not well controlled. This includes lifestyle habits as well as pharmaceutical treatment. Although the participants in this study cannot be considered a representative sample of the German population and occasional measurements without standardization further limit firm conclusions, the BP, plasma glucose, and HbA results indicate that a major proportion of PWD have insufficient metabolic and BP control. The marked increase in the proportion of T2D among all participants over time is consistent with the increasing prevalence of T2D mellitus found in many other countries worldwide in the recent decades. Our findings underline the importance of an optimized therapy for further improvement of disease management in those already diagnosed with this common chronic, progressive disease.
在“了解糖尿病的关键因素:血糖低于7更健康”糖尿病宣传活动期间,2005年至2014年期间,超过30000名随机参与的个体接受了不定期的自愿糖尿病风险检查。
该活动旨在向德国民众宣传糖尿病及其并发症、2型糖尿病(T2D)发生的既定风险因素、其在现实人群中的患病率及管理、有确诊糖尿病病史的参与者(糖尿病患者)的风险因素控制质量和实际疾病管理情况。除了人口统计学特征(如性别、年龄)和既往史信息(抗高血压治疗、血浆葡萄糖水平升高史、遗传易感性)外,风险因素评估还包括体重指数(BMI)、腰围和生活方式(体育活动、营养习惯)。所要求的信息通过直接测量血压(BP)(常规)、血浆葡萄糖和糖化血红蛋白(HbA)(自愿)进行补充。2005年至2014年期间,超过31000名个体参与了德国众多城市的45次单次活动。在此,我们报告已知糖尿病患者亚组的结果。
在2006 - 2014年参与问卷调查的26522名个体中,21055名参与者(79.4%)无糖尿病病史,5098名个体(19.2%)报告被诊断为T2D,369名(1.4%)为1型糖尿病。多年来,T2D参与者的比例从2006年的13.3%显著增加至2014年的21.7%。64岁以上年龄组是该亚组中最大的群体(67.3%),男性占48.4%,女性占51.6%。糖尿病患者中超重或肥胖的患病率分别为78%和69.2%。超过40%的T2D个体没有规律的体育锻炼,超过15%的个体有不良营养习惯。总体而言,69.9%的T2D参与者在活动期间评估的血压升高或曾报告在任何时间接受过抗高血压药物治疗。平均而言,几乎一半的糖尿病患者(46.3%)糖化血红蛋白高于7.0%;在10年期间观察到显著的升高趋势。
对参与“了解糖尿病的关键因素:血糖低于7更健康”活动的糖尿病患者的分析表明,尽管过去付出了巨大努力,但T2D进展和并发症的重要方面仍未得到良好控制。这包括生活方式习惯以及药物治疗。尽管本研究中的参与者不能被视为德国人群的代表性样本,且无标准化的不定期测量进一步限制了确切结论,但血压、血浆葡萄糖和糖化血红蛋白结果表明,很大一部分糖尿病患者的代谢和血压控制不足。随着时间的推移,所有参与者中T2D比例的显著增加与近几十年来世界许多其他国家T2D患病率的上升一致。我们的研究结果强调了优化治疗对于进一步改善已诊断患有这种常见慢性进展性疾病患者的疾病管理的重要性。