Department of Odontology, Cariology Section, Umeå University, 901 87 Umeå, Sweden.
J Dent Res. 2011 Oct;90(10):1183-8. doi: 10.1177/0022034511418973. Epub 2011 Aug 9.
Establishment of the microbiota of the gut has been shown to differ between infants delivered by Caesarian section (C-section) and those delivered vaginally. The aim of the present study was to compare the oral microbiota in infants delivered by these different routes. The oral biofilm was assayed by the Human Oral Microbe Identification Microarray (HOMIM) in healthy three-month-old infants, 38 infants born by C-section, and 25 infants delivered vaginally. Among over 300 bacterial taxa targeted by the HOMIM microarray, Slackia exigua was detected only in infants delivered by C-section. Further, significantly more bacterial taxa were detected in the infants delivered vaginally (79 species/species clusters) compared with infants delivered by C-section (54 species/species clusters). Multivariate modeling revealed a strong model that separated the microbiota of C-section and vaginally delivered infants into two distinct colonization patterns. In conclusion, our study indicated differences in the oral microbiota in infants due to mode of delivery, with vaginally delivered infants having a higher number of taxa detected by the HOMIM microarray.
剖宫产（C -section）和阴道分娩婴儿的肠道微生物群建立已被证明存在差异。本研究旨在比较经不同分娩方式婴儿的口腔微生物群。通过人类口腔微生物鉴定微阵列（HOMIM）检测健康三个月大的婴儿、38 名剖宫产婴儿和 25 名阴道分娩婴儿的口腔生物膜。在 HOMIM 微阵列靶向的 300 多种细菌分类群中，仅在剖宫产婴儿中检测到 Slackia exigua。此外，阴道分娩婴儿（79 个种/种簇）中检测到的细菌分类群明显多于剖宫产婴儿（54 个种/种簇）。多变量建模揭示了一个强有力的模型，将 C -section 和阴道分娩婴儿的微生物群分离成两种不同的定植模式。总之，我们的研究表明，由于分娩方式的不同，婴儿口腔微生物群存在差异，阴道分娩婴儿通过 HOMIM 微阵列检测到的细菌分类群数量更多。
