Krech T, de Chastonay J, Falsen E
Institute for Medical Microbiology and Virology of the University, Düsseldorf, FRG.
Eur J Clin Microbiol Infect Dis. 1988 Apr;7(2):232-7. doi: 10.1007/BF01963094.
Several methods for epidemiological typing of Corynebacterium diphtheriae were compared with the well accepted phage typing analysis. For this purpose, isolates from outbreaks of diphtheria in specific areas of the FRG and Sweden were analyzed by phage typing, their bacterial polypeptide profiles were examined and their phage-DNA restriction enzyme patterns were compared. All techniques were able to identify whether certain outbreaks were epidemiologically linked or not. Phage typing and phage-DNA restriction enzyme fragment analysis were limited in their application to lysogenic strains, whereas bacterial polypeptide analysis was universally applicable. Analysis of bacterial polypeptides was superior to all methods, especially in terms of speed and simplicity.
将几种白喉棒状杆菌的流行病学分型方法与广泛认可的噬菌体分型分析进行了比较。为此，对来自联邦德国和瑞典特定地区白喉暴发的分离株进行了噬菌体分型分析，检测了它们的细菌多肽谱，并比较了它们的噬菌体DNA限制性酶切图谱。所有技术都能够确定某些暴发在流行病学上是否存在关联。噬菌体分型和噬菌体DNA限制性酶切片段分析仅适用于溶原性菌株，而细菌多肽分析则普遍适用。细菌多肽分析优于所有方法，尤其是在速度和简便性方面。
