Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, Republic of Korea.
Nanotechnology. 2017 May 5;28(18):185102. doi: 10.1088/1361-6528/aa66b0. Epub 2017 Apr 10.
Here we report indocyanine green (ICG)-loaded hollow mesoporous silica nanoparticles (ICG@HMSNP) as an activatable theranostic platform. Near-infrared fluorescence and singlet oxygen generation of ICG@HMSNP was effectively quenched (i.e. turned off) in its native state because of the fluorescence resonance energy transfer between ICG molecules. Therefore, ICG@HMSNP was nonfluorescent and nonphototoxic in the extracellular region. After the nanoparticles entered the cancer cells via endocytosis, they became highly fluorescent and phototoxic. In addition, intracellular uptake of ICG@HMSNP was 2.75 times higher than that of free ICG, resulting in an enhanced phototherapy of cancer.
在这里，我们报告了负载吲哚菁绿（ICG）的中空介孔硅纳米粒子（ICG@HMSNP）作为一种可激活的治疗平台。由于 ICG 分子之间的荧光共振能量转移，ICG@HMSNP 的近红外荧光和单线态氧生成在其原始状态下被有效猝灭（即关闭）。因此，ICG@HMSNP 在细胞外区域是非荧光和非光毒性的。当纳米粒子通过内吞作用进入癌细胞后，它们变得高度荧光和光毒性。此外，ICG@HMSNP 的细胞内摄取量是游离 ICG 的 2.75 倍，从而增强了癌症的光疗效果。
