Hong Suk Ho, Kim Hyunjin, Choi Yongdoo
Research Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea.
Chem Asian J. 2017 Jul 18;12(14):1700-1703. doi: 10.1002/asia.201700371. Epub 2017 Jun 8.
Here we show that "off-on" type of photodynamic therapy agents could be developed using hollow mesoporous silica nanoparticles (HMSNPs), which can be used not only for enhancing delivery of photosensitizers to cancer cells but also for enabling switchable optical properties of the photosensitizers. Fluorescence and singlet oxygen generation of the photosensitizer-loaded HMSNP are turned off in its native state. In vitro cell studies showed that this HMSNP-based "off-on" agent may have potential utility in selective fluorescence detection and photodynamic therapy of cancers.
在此我们表明，可以使用中空介孔二氧化硅纳米颗粒（HMSNP）开发“开启-关闭”型光动力治疗剂，其不仅可用于增强光敏剂向癌细胞的递送，还能使光敏剂具有可切换的光学特性。负载光敏剂的HMSNP在其天然状态下荧光和单线态氧生成被关闭。体外细胞研究表明，这种基于HMSNP的“开启-关闭”剂在癌症的选择性荧光检测和光动力治疗中可能具有潜在应用价值。
