一种从夹竹桃内生真菌青霉属菌株中分离得到的新型对羟基苯甲酸衍生物。
A new p-hydroxybenzoic acid derivative from an endophytic fungus Penicillium sp. of Nerium indicum.
作者信息
Ma Yang-Min, Qiao Ke, Kong Yang, Guo Lin-Xin, Li Meng-Yun, Fan Chao
机构信息
a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry , Ministry of Education, Shaanxi University of Science and Technology , Xi'an 710021 , China.
b School of Food and Biological Engineering , Shaanxi University of Science and Technology , Xi'an 710021 , China.
出版信息
J Asian Nat Prod Res. 2017 Dec;19(12):1245-1251. doi: 10.1080/10286020.2017.1313240. Epub 2017 Apr 11.
A new p-hydroxybenzoic acid derivative named 4-(2'R, 4'-dihydroxybutoxy) benzoic acid (1) was isolated from the fermentation of Penicillium sp. R22 in Nerium indicum. The structure was elucidated by means of spectroscopic (HR-ESI-MS, NMR, IR, UV) and X-ray crystallographic methods. The antibacterial and antifungal activity of compound 1 was tested, and the results showed that compound 1 revealed potent antifungal activity against Colletotrichum gloeosporioides, Alternaria alternata, and Alteranria brassicae with MIC value of 31.2 μg/ml.
从夹竹桃青霉R22在夹竹桃中的发酵产物中分离出一种新的对羟基苯甲酸衍生物，命名为4-(2'R, 4'-二羟基丁氧基)苯甲酸(1)。通过光谱(高分辨电喷雾电离质谱、核磁共振、红外光谱、紫外光谱)和X射线晶体学方法对其结构进行了鉴定。测试了化合物1的抗菌和抗真菌活性，结果表明化合物1对胶孢炭疽菌、链格孢和芸苔链格孢具有较强的抗真菌活性，最低抑菌浓度值为31.2μg/ml。
Zotero 插件