Zhao Ting, Xu Lu-Lin, Zhang Yan, Lin Zheng-Hong, Xia Tao, Yang Deng-Feng, Chen Ye-Miao, Yang Xiao-Long
a Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University , Chongqing 401331 , China.
b School of Life Sciences, Chongqing University , Chongqing 401331 , China.
J Asian Nat Prod Res. 2019 Sep;21(9):851-858. doi: 10.1080/10286020.2018.1495197. Epub 2018 Aug 21.
Three new 3,4,6-trisubstituted α-pyrone derivatives, namely 6-(2'-hydroxy-3',5'-diene-1'-heptyl)-4-hydroxy-3-methyl-2H-pyran-2-one (), 6-(2'-hydroxy-5'-ene-1'-heptyl)-4-hydroxy-3-methyl-2H-pyran-2-one (), and 6-(2'-hydroxy-1'-heptyl)-4 -hydroxy-3-methyl-2H-pyran-2-one (), together with one known compound trichodermic acid (), were isolated from the solid-substrate fermentation culture of associated the roots of . Compounds displayed the antimicrobial activity selectively against tested fungal and bacterial strains with minimum inhibitory concentration (MIC) values ranging from 12.5 to 100 μg/ml. Furthermore, we found that only compound exhibited moderate cytotoxicity against five human cancer cells (A549, LN229, MGC, LOVO, and MDA231) with IC values of 51.45, 23.43, 39.16, 46.97, and 42.85 μg/ml, respectively.
从与 根部相关的固体基质发酵培养物中分离出三种新的3,4,6-三取代α-吡喃酮衍生物，即6-(2'-羟基-3',5'-二烯-1'-庚基)-4-羟基-3-甲基-2H-吡喃-2-酮（）、6-(2'-羟基-5'-烯-1'-庚基)-4-羟基-3-甲基-2H-吡喃-2-酮（）和6-(2'-羟基-1'-庚基)-4-羟基-3-甲基-2H-吡喃-2-酮（），以及一种已知化合物曲酸（）。化合物 对测试的真菌和细菌菌株表现出选择性抗菌活性，最低抑菌浓度（MIC）值范围为12.5至100μg/ml。此外，我们发现只有化合物 对五种人类癌细胞（A549、LN229、MGC、LOVO和MDA231）表现出中等细胞毒性，IC值分别为51.45, 23.43, 39.16, 46.97和42.85μg/ml。
