Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, 571158, Haikou, People's Republic of China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, 571158, Haikou, People's Republic of China.
J Antibiot (Tokyo). 2019 Jul;72(7):513-517. doi: 10.1038/s41429-019-0178-8. Epub 2019 Apr 1.
Three new polyketides, (2S)-2,3-dihydro-5,6-dihydroxy-2-methyl-4H-1-benzopyran-4-one (1), (2'R)-2-(2'-hydroxypropyl)-4-methoxyl-1,3-benzenediol (2), and 4-ethyl-3-hydroxy-6-propenyl-2H-pyran-2-one (3) were isolated from the culture broth of Colletotrichum gloeosporioides, an endophytic fungus derived from the mangrove Ceriops tagal. The structures of 1-3 were elucidated on the basis of NMR spectra and HR-ESI-MS data. Their absolute configurations were determined by comparing with the experimental and calculated ECD spectrum. Compounds 1 and 3 showed potent antibacterial activities against some of the tested microbes.
从红树林内生真菌胶孢炭疽菌（Colletotrichum gloeosporioides）的发酵液中分离得到三个新的多酮化合物，（2S）-2,3-二氢-5,6-二羟基-2-甲基-4H-1-苯并吡喃-4-酮（1）、（2'R）-2-（2'-羟基丙基）-4-甲氧基-1,3-苯二酚（2）和 4-乙基-3-羟基-6-丙烯基-2H-吡喃-2-酮（3）。根据 NMR 光谱和 HR-ESI-MS 数据阐明了 1-3 的结构。通过与实验和计算的 ECD 光谱比较，确定了它们的绝对构型。化合物 1 和 3 对一些测试的微生物表现出很强的抗菌活性。
