Jiang Manli, Bennani N Nora, Feldman Andrew L
a Department of Laboratory Medicine and Pathology , Mayo Clinic , Rochester , MN , USA.
b Division of Hematology , Mayo Clinic , Rochester , MN , USA.
Expert Rev Hematol. 2017 May;10(5):405-415. doi: 10.1080/17474086.2017.1318053. Epub 2017 Apr 24.
Lymphomas are classified based on the normal counterpart, or cell of origin, from which they arise. Because lymphocytes have physiologic immune functions that vary both by lineage and by stage of differentiation, the classification of lymphomas arising from these normal lymphoid populations is complex. Recent genomic data have contributed additional complexity. Areas covered: Lymphoma classification follows the World Health Organization (WHO) system, which reflects international consensus and is based on pathological, genetic, and clinical factors. A 2016 revision to the WHO classification of lymphoid neoplasms recently was reported. The present review focuses on B-cell non-Hodgkin lymphomas, the most common group of lymphomas, and summarizes recent changes most relevant to hematologists and other clinicians who care for lymphoma patients. Expert commentary: Lymphoma classification is a continually evolving field that needs to be responsive to new clinical, pathological, and molecular understanding of lymphoid neoplasia. Among the entities covered in this review, the 2016 revision of the WHO classification particularly impact the subclassification and genetic stratification of diffuse large B-cell lymphoma and high-grade B-cell lymphomas, and reflect evolving criteria and nomenclature for indolent B-cell lymphomas and lymphoproliferative disorders.
淋巴瘤是根据其起源的正常对应细胞或细胞来源进行分类的。由于淋巴细胞具有因谱系和分化阶段而异的生理免疫功能，因此源自这些正常淋巴样群体的淋巴瘤分类很复杂。近期的基因组数据又增加了复杂性。涵盖领域：淋巴瘤分类遵循世界卫生组织（WHO）系统，该系统反映了国际共识，并基于病理、遗传和临床因素。最近报道了2016年WHO淋巴样肿瘤分类的修订版。本综述重点关注最常见的淋巴瘤类型——B细胞非霍奇金淋巴瘤，并总结了与治疗淋巴瘤患者的血液科医生和其他临床医生最相关的近期变化。专家评论：淋巴瘤分类是一个不断发展的领域，需要对淋巴样肿瘤新的临床、病理和分子认识做出反应。在本综述涵盖的实体中，2016年WHO分类的修订对弥漫性大B细胞淋巴瘤和高级别B细胞淋巴瘤的亚分类和基因分层有特别影响，并反映了惰性B细胞淋巴瘤和淋巴增殖性疾病不断演变的标准和命名法。
