感染人类免疫缺陷病毒者中抗Epstein-Barr病毒核抗原2B抗体的流行率。

Prevalence of antibodies to Epstein-Barr virus nuclear antigen 2B in persons infected with the human immunodeficiency virus.

作者信息

Sculley T B, Cross S M, Borrow P, Cooper D A

机构信息

Queensland Institute of Medical Research, Herston, Brisbane, Australia.

出版信息

J Infect Dis. 1988 Jul;158(1):186-92. doi: 10.1093/infdis/158.1.186.

DOI:10.1093/infdis/158.1.186

PMID:2839581

Abstract

We measured the presence of antibodies to the Epstein-Barr virus (EBV) nuclear antigen 2B (EBNA2B) in patients with AIDS and related disorders, persons with human immunodeficiency virus (HIV) infection, persons at risk for HIV infection, and normal persons. Sera from 38% (16 of 43) of the patients with AIDS and 35% (43 of 123) of HIV-positive individuals reacted with EBNA2B, versus 25% (21 of 83) of the high-risk patients and 7.5% (5 of 65) of the normal persons. Screening these sera against cell lines that express EBNA2B, EBNA2A, or neither antigen revealed that only a proportion of these sera contained EBNA2B-specific antibodies. Many sera reacted with both antigens. Of the EBNA2B-specific sera, 14% (6 of 43) were from patients with AIDS, 16% (20 of 123) from HIV-positive individuals, 5% (4 of 83) from high-risk individuals, and 4.5% (3 of 65) from normal persons. The presence of antibodies to the EBNA2B in HIV-infected individuals indicates that they may be infected with type B strains of EBV.

摘要

我们检测了艾滋病及相关疾病患者、人类免疫缺陷病毒（HIV）感染者、HIV感染高危人群以及正常人中针对EB病毒（EBV）核抗原2B（EBNA2B）的抗体情况。38%（43例中的16例）的艾滋病患者血清以及35%（123例HIV阳性个体中的43例）的血清与EBNA2B发生反应，相比之下，高危患者中有25%（83例中的21例），正常人中有7.5%（65例中的5例）出现反应。用表达EBNA2B、EBNA2A或两种抗原均不表达的细胞系对这些血清进行筛查发现，这些血清中只有一部分含有EBNA2B特异性抗体。许多血清与两种抗原都发生反应。在EBNA2B特异性血清中, 14%（43例中的6例）来自艾滋病患者，16%（123例中的20例）来自HIV阳性个体，5%（83例中的4例）来自高危个体，4.5%（65例中的3例）来自正常人。HIV感染者体内存在针对EBNA2B的抗体表明，他们可能感染了EBV的B型毒株。