Padmini Nagarajan, Ajilda Antony Alex Kennedy, Sivakumar Natesan, Selvakumar Gopal
Department of Microbiology, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, India.
School of Biotechnology, Madurai Kamaraj University, Madurai, Tamil Nadu, India.
J Basic Microbiol. 2017 Jun;57(6):460-470. doi: 10.1002/jobm.201700008. Epub 2017 Apr 11.
Drug resistance is a phenomenon where by an organism becomes fully or partially resistant to drugs or antibiotics being used against it. Antibiotic resistance poses an exacting intimidation for people with underlying medical immune conditions or weakened immune systems. Infections caused by the enzyme extended spectrum β-lactamase (ESBL) producing multi drug resistance (MDR) Enterobacteriaceae especially Escherichia coli and Klebsiella pneumoniae are resistant to a broad range of beta lactams, including third generation cephalosporins. Among all the pathogens, these two MDR E. coli and K. pneumoniae have emerged as one of the world's greatest health threats in past two decades. The nosocomial infections caused by these ESBL producing MDR E. coli and K. pneumoniae complicated the therapy and limit treatment options.
耐药性是一种生物体对用于对抗它的药物或抗生素产生完全或部分抗性的现象。抗生素耐药性对患有潜在医学免疫疾病或免疫系统较弱的人构成了严峻威胁。由产生超广谱β-内酰胺酶（ESBL）的多重耐药（MDR）肠杆菌科细菌，尤其是大肠杆菌和肺炎克雷伯菌引起的感染，对包括第三代头孢菌素在内的多种β-内酰胺类药物具有抗性。在所有病原体中，这两种多重耐药的大肠杆菌和肺炎克雷伯菌在过去二十年中已成为全球最大的健康威胁之一。由这些产生ESBL的多重耐药大肠杆菌和肺炎克雷伯菌引起的医院感染使治疗变得复杂，并限制了治疗选择。
