Bomann Anne Cathrine, Jørgensen Martin Balslev, Bo Sune, Nielsen Marianne, Gede Lene Bjerring, Elfving Betina, Simonsen Erik
Psychiatric Research Unit, Region Zealand, Faelledvej 6, 4200, Slagelse, Denmark.
Institute for Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Edel Sauntes Alle 10, 2100, Copenhagen, Denmark.
Personal Ment Health. 2017 May;11(2):91-100. doi: 10.1002/pmh.1369. Epub 2017 Apr 11.
Social deficits and emotional dysregulation have been suggested as explanations for the relational difficulties experienced by patients with borderline personality disorder (BPD). The neuropeptide oxytocin (OXT) is a possible neurobiological underpinning of these adversities, and this study examines possible correlations between BPD symptomatology and serum OXT.
Thirty-eight female participants (BPD group n = 18, matched control group n = 20) with a mean age of 29.5 years (standard deviation 9.2) were assessed for personality disorders, general psychopathology, childhood trauma and perceived stress. OXT was measured in serum samples.
We found no significant difference between patient and control group in terms of OXT levels. However, post hoc analysis showed a relationship in the patient group between civil status and OXT (p < 0.05), indicating higher levels of OXT for patients in a romantic relationship.
The idea of OXT as a pro-social love hormone is perhaps too simplistic, and factors like attachment style, exposure to trauma and psychiatric disorders must be considered in order to understand its diverse functions.
Contrary to our expectations, we did not find lower serum OXT levels in the BPD group. However, BPD patients in a romantic relationship had higher levels of serum OXT than single BPD patients. Copyright © 2017 John Wiley & Sons, Ltd.
社交缺陷和情绪失调被认为是边缘型人格障碍（BPD）患者人际关系困难的原因。神经肽催产素（OXT）可能是这些不良状况的神经生物学基础，本研究探讨了BPD症状与血清OXT之间可能存在的相关性。
对38名平均年龄为29.5岁（标准差9.2）的女性参与者（BPD组n = 18，匹配对照组n = 20）进行人格障碍、一般精神病理学、童年创伤和感知压力评估。在血清样本中测量OXT。
我们发现患者组和对照组在OXT水平方面没有显著差异。然而，事后分析显示患者组中婚姻状况与OXT之间存在关联（p < 0.05），表明处于恋爱关系中的患者OXT水平较高。
将OXT视为亲社会爱情激素的观点可能过于简单，为了理解其多种功能，必须考虑依恋风格、创伤暴露和精神疾病等因素。
与我们的预期相反，我们并未发现BPD组血清OXT水平较低。然而，处于恋爱关系中的BPD患者血清OXT水平高于单身BPD患者。版权所有© 2017约翰威立父子有限公司。
