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原癌基因fos的转录自调控

Transcriptional autoregulation of the proto-oncogene fos.

作者信息

Sassone-Corsi P, Sisson J C, Verma I M

机构信息

Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92138.

出版信息

Nature. 1988 Jul 28;334(6180):314-9. doi: 10.1038/334314a0.

DOI:10.1038/334314a0
PMID:2839774
Abstract

Serum-induced transcription of the proto-oncogene fos is under negative feedback regulation mediated by the fos protein. The fos promoter region responsive to repression is also required for serum inducibility and binds a nucleoprotein complex in which the nuclear factor AP-1 is associated with fos protein.

摘要

原癌基因fos的血清诱导转录受到由fos蛋白介导的负反馈调节。对抑制有反应的fos启动子区域对于血清诱导性也是必需的，并且结合一种核蛋白复合物，其中核因子AP-1与fos蛋白相关联。

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