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Photodiagnosis Photodyn Ther. 2017 Dec;20:159-164. doi: 10.1016/j.pdpdt.2017.06.002. Epub 2017 Jun 30.
3
Treatment of recalcitrant erosive oral lichen planus and desquamative gingivitis with oral apremilast.口服阿普司特治疗顽固性糜烂性口腔扁平苔藓和剥脱性龈炎
J Dermatol Case Rep. 2016 Nov 30;10(3):56-57. doi: 10.3315/jdcr.2016.1232.
4
The presence of Helicobacter pylori in oral cavities of patients with leukoplakia and oral lichen planus.白斑病和口腔扁平苔藓患者口腔中幽门螺杆菌的存在情况。
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Oral lichen planus to oral lichenoid lesions: Evolution or revolution.从口腔扁平苔藓到口腔苔藓样病变：演变还是变革。
J Oral Maxillofac Pathol. 2015 Sep-Dec;19(3):364-70. doi: 10.4103/0973-029X.174632.
6
No evidence for Helicobacter pylori in oral lichen planus.口腔扁平苔藓中无幽门螺杆菌感染的证据。
J Oral Pathol Med. 2014 Sep;43(8):576-8. doi: 10.1111/jop.12194. Epub 2014 Apr 25.
7
Relationship between Lichen Planus and Helicobacter pylori Infection.扁平苔藓与幽门螺杆菌感染之间的关系。
J Dent Res Dent Clin Dent Prospects. 2010 Winter;4(1):17-20. doi: 10.5681/joddd.2010.005. Epub 2010 Mar 14.
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Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management.口腔和口咽黏膜的潜在恶性疾病；术语、分类和当前的治疗概念。
Oral Oncol. 2009 Apr-May;45(4-5):317-23. doi: 10.1016/j.oraloncology.2008.05.016. Epub 2008 Jul 31.
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Oral Dis. 2006 Mar;12(2):112-6. doi: 10.1111/j.1601-0825.2005.01165.x.
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口腔扁平苔藓患者治疗的短期后果：一项前瞻性研究。

Short-term consequences of treatment in patients with oral lichen planus: A prospective study.

作者信息

Javadzadeh Farshad, Shirmohamadi Masoud, Hosseinpour Sarmadi Maryam, Ghojazadeh Morteza, Bohlouli Sepideh, Ghorbanihaghjo Amir, Pourzare Solmaz

机构信息

Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

J Adv Periodontol Implant Dent. 2022 Oct 9;15(1):42-46. doi: 10.34172/japid.2023.004. eCollection 2023.

DOI:10.34172/japid.2023.004
PMID:37645554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10460783/
Abstract

BACKGROUND

Oral lichen planus (OLP) is a multifactorial chronic inflammatory condition with unknown etiology. This condition has been associated with . This study aimed to investigate the relationship between the treatment of infection and improvements in OLP lesions.

METHODS

In this cohort study, 42 patients with erosive or ulcerative OLP lesions were evaluated in terms of infection using the stool antigen (HpSA) test. The patients were divided into three groups. The first group consisted of 12 -negative patients. The second group consisted of 21 -positive patients receiving antibacterial treatment. The third group included nine -positive patients not willing to receive treatment. All the three groups underwent the usual OLP treatment. Patients in the second and third groups were re-evaluated by the HpSA test after two months. The efficacy indexes and visual analog scale were used to evaluate clinical improvements.

RESULTS

The efficiency index and pain scores were affected by the intervention (<0.001). The logistic regression analysis showed that the severity index before treatment was significantly effective (OR=0.745 (95% CI: 0.602‒0.923; =0.007). No statistical significance for factors affecting other variables (>0.05) was obtained.

CONCLUSION

Pain intensity was higher in patients with than in those without before treatment. Also, in patients with , the treatment affects the complete recovery rate.

摘要

背景

口腔扁平苔藓（OLP）是一种病因不明的多因素慢性炎症性疾病。这种疾病与……有关。本研究旨在探讨治疗……感染与OLP病变改善之间的关系。

方法

在这项队列研究中，使用……粪便抗原（HpSA）检测对42例糜烂性或溃疡性OLP病变患者的……感染情况进行评估。患者被分为三组。第一组由12例……阴性患者组成。第二组由21例接受抗菌治疗的……阳性患者组成。第三组包括9例不愿接受治疗的……阳性患者。所有三组均接受常规的OLP治疗。第二组和第三组的患者在两个月后通过HpSA检测进行重新评估。使用疗效指标和视觉模拟量表来评估临床改善情况。

结果

干预对疗效指标和疼痛评分有影响（<0.001）。逻辑回归分析表明，治疗前的严重程度指数具有显著效果（OR = 0.745（95% CI：0.602 - 0.923；= 0.007）。未获得影响其他变量的因素的统计学意义（>0.05）。

结论

治疗前，……阳性患者的疼痛强度高于……阴性患者。此外，对于……阳性患者，治疗会影响完全恢复率。