水溶性聚噻吩用于癌症的双光子激发荧光成像和光动力疗法。
Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer.
机构信息
Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS) , Beijing, China.
School of Future Technology, University of Chinese Academy of Sciences , Beijing, China.
出版信息
ACS Appl Mater Interfaces. 2017 May 3;9(17):14590-14595. doi: 10.1021/acsami.6b15537. Epub 2017 Apr 24.
Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong O generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.
设计并合成了一种带正电荷的水溶性聚噻吩（PT0），它可以在纯水溶液中自组装成纳米颗粒。PT0 表现出了高的光稳定性和 pH 稳定性、良好的生物相容性、较强的 O2 生成能力和大的双光子吸收截面。此外，我们还表明，PT0 的荧光不受生物分子和金属离子的干扰。作为一个应用实例，PT0 被证明能够在单光子或双光子激发模式下同时进行细胞成像和光动力治疗。
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