Vigdor S E, Klyachko A V, Solberg K A, Pankuch M
Phenix Medical LLC, Bloomington, IN 47404, United States of America.
Phys Med Biol. 2017 Jun 21;62(12):4946-4969. doi: 10.1088/1361-6560/aa6ce2. Epub 2017 Apr 12.
In order to address dosimetry demands during proton therapy treatments utilizing pencil beam scanning and/or pulsed beam accelerators, we have developed a xenon-filled gas scintillation detector (GSD) that can monitor delivered dose and 2D beam centroid position pulse-by-pulse in real time, with high response linearity up to high instantaneous dose rates. We present design considerations for the GSD and results of beam tests carried out at operating proton therapy clinics. In addition to demonstrating spatial resolution with σ of a few hundred microns in each transverse dimension and relative dose precision better than 1% over large treatment areas, the test beam results also reveal the dependence of the GSD dose normalization on dose rate, beam energy, and gas impurities. The results demonstrate the promise of the GSD technology to provide an important addition to dosimetry approaches for next-generation ion beam therapy.
为了满足在使用笔形束扫描和/或脉冲束加速器的质子治疗过程中的剂量测定需求，我们开发了一种充氙气的气体闪烁探测器（GSD），它能够实时逐脉冲监测输送剂量和二维束质心位置，在高达高瞬时剂量率的情况下具有高响应线性。我们介绍了GSD的设计考量以及在运行中的质子治疗诊所进行的束流测试结果。除了在每个横向维度上展示出几百微米的σ空间分辨率以及在大治疗区域内相对剂量精度优于1%之外，测试束流结果还揭示了GSD剂量归一化对剂量率、束流能量和气体杂质的依赖性。结果表明，GSD技术有望为下一代离子束治疗的剂量测定方法增添重要内容。
