Jia Yunlu, Chen Yongxia, Wang Qinchuan, Jayasinghe Ushani, Luo Xiao, Wei Qun, Wang Ji, Xiong Hanchu, Chen Cong, Xu Bin, Hu Wenxian, Wang Linbo, Zhao Wenhe, Zhou Jichun
Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, Zhejiang, China.
Oncotarget. 2017 Jun 20;8(25):41717-41733. doi: 10.18632/oncotarget.16684.
Exosomes are nano-sized membrane vesicles released by a variety of cell types, and are thought to play important roles in intercellular communications. In breast cancer, through horizontal transfer of various bioactive molecules, such as proteins and mRNAs, exosomes are emerging as local and systemic cell-to-cell mediators of oncogenic information and play an important role on cancer progression. This review outlines the current knowledge and concepts concerning the exosomes involvement in breast cancer pathogenesis (including tumor initiation, invasion and metastasis, angiogenesis, immune system modulation and tumor microenvironment) and cancer therapy resistance. Moreover, the potential use of exosomes as promising diagnostic and therapeutic biomarkers in breast cancer are also discussed.
外泌体是由多种细胞类型释放的纳米级膜泡，被认为在细胞间通讯中发挥重要作用。在乳腺癌中，外泌体通过蛋白质和mRNA等各种生物活性分子的水平转移，正成为致癌信息的局部和全身细胞间介质，并在癌症进展中发挥重要作用。本文综述了关于外泌体参与乳腺癌发病机制（包括肿瘤发生、侵袭和转移、血管生成、免疫系统调节和肿瘤微环境）以及癌症治疗耐药性的当前知识和概念。此外，还讨论了外泌体作为乳腺癌有前景的诊断和治疗生物标志物的潜在用途。
