Maj Joanna, Jankowska-Konsur Alina, Gruber Joanna, Woźniak Zdzisław, Nockowski Piotr, Hryncewicz-Gwóźdź Anita
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University Department of Pathomorphology, Wroclaw Medical University, Wroclaw, Poland.
Medicine (Baltimore). 2017 Apr;96(15):e6470. doi: 10.1097/MD.0000000000006470.
Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications.
A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization.
Histological and immunohistochemical examinations of DMC biopsy indicated melanoma metastatic cells as well as free deposits of melanin and melanophage presence in the dermis.
The patient refused to the treatment.
The patient died eight months after DMC appeared.
DMC is a rare presentation of advanced MM and is a bad prognostic factor. The pathomechanisms of the discoloration of the skin are not fully explained. The role of micrometastases, as well as melanin precursors, released during lysis of MM metastases, and growth factors may play a role in the development of the symptom.
皮肤弥漫性黑变病（DMC）是恶性黑色素瘤进展的一种非常罕见的体征。这种情况通常在黑色素瘤诊断后约一年，在患有转移性肿瘤的患者中出现，并在使用细胞抑制药物进行抗癌治疗后发生。
一名72岁的白种男性因皮肤弥漫性黑变病入住皮肤科4个月，有30年前和此次住院前9个月接受过两次手术治疗黑色素瘤的病史。
皮肤弥漫性黑变病活检的组织学和免疫组化检查表明真皮中有黑色素瘤转移细胞以及游离的黑色素沉积和噬黑素细胞。
患者拒绝治疗。
皮肤弥漫性黑变病出现8个月后患者死亡。
皮肤弥漫性黑变病是晚期黑色素瘤的罕见表现，是一个不良预后因素。皮肤变色的发病机制尚未完全阐明。微小转移灶以及黑色素瘤转移灶溶解过程中释放的黑色素前体和生长因子可能在该症状的发生中起作用。
