Schuler G, Hönigsmann H, Wolff K
J Am Acad Dermatol. 1980 Oct;3(4):363-9.
Electron microscopy (EM) and electron microscopic cytochemistry have shown that diffuse melanosis in advanced metastatic melanoma is the result of an unlimited spread of single melanoma cells throughout the dermis; these cells retain their melanogenic capacity and continue to produce melanized melanosomes which eventually are deposited within dermal macrophages and thus impart to the skin a diffuse slate-blue color. These findings are in accordance with previous observations in a similar patient and thus support the concept that single cell metastasis represents a common pathogenic event in these patients.
电子显微镜（EM）及电子显微镜细胞化学研究表明，晚期转移性黑色素瘤中的弥漫性黑变病是单个黑色素瘤细胞在整个真皮层无限制扩散的结果；这些细胞保留了其黑素生成能力，并继续产生黑素化的黑素小体，这些黑素小体最终沉积在真皮巨噬细胞内，从而使皮肤呈现弥漫性石板蓝色。这些发现与之前对一名类似患者的观察结果一致，因此支持了单细胞转移是这些患者常见致病事件的这一概念。
