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[移动元件jockey对黑腹果蝇cut基因座插入突变抑制作用的影响]

[Effect of the mobile element jockey on the suppression of insertion mutations in the cut locus of Drosophila melanogaster].

作者信息

Gerasimova T I, Trubetskaia N V, Georgiev P G, Kochieva E Z, Churikov N A

出版信息

Genetika. 1988 Apr;24(4):756-9.

PMID:2840343
Abstract

The data are reported on suppression of mutations at the cut locus induced by a mdg4 insertion carrying the other mobile element, "jockey". All mutations containing mdg4 with the jockey (ctMRpN) are suppressed by a classic suppressor su(Hw)2 and two new alleles obtained in this work. The extent of suppression increases, depending on the orientation of the jockey in mdg4 up to the point, when su(Hw) alleles known as recessive become semi-dominant. The jockey and mdg4 have been also found to influence the locus transcription in the norm and in case of suppression.

摘要

报告了携带另一种移动元件“jockey”的mdg4插入所诱导的切割位点突变抑制的数据。所有含有带jockey的mdg4的突变(ctMRpN)都被经典抑制因子su(Hw)2和本研究中获得的两个新等位基因所抑制。抑制程度会增加,这取决于jockey在mdg4中的方向,直至达到一个点,此时被认为是隐性的su(Hw)等位基因变为半显性。还发现jockey和mdg4在正常情况下以及抑制情况下都会影响该位点的转录。

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