Georgiev P G, Gerasimova T I
Genetika. 1989 Aug;25(8):1409-19.
The aim of the present work was to obtain mutations in the genes involved in regulation of the yellow locus and mdg4. For this purpose, we searched for mutations changing phenotypic expression of the y(2) mutation induced by mdg4 insertion into the regulatory region of the yellow locus. Mutations have been obtained in the earlier described system of prolonged genome instability, sometimes combined with P-M hybrid dysgenesis. The mutation mod(mdg4) in a novel gene, modifier of mdg4, was detected which either enhanced or suppressed a phenotypic expression of several mutations induced by mdg4 insertion. We suggest that mod(mdg4) controls the expression of mdg4. In addition, the mutations in five loci located on the X chromosome have been found which enhanced the mutation phenotype of several y alleles induced by insertions of different mobile elements in the regulatory region of the latter. Possibly, the protein products of these genes designated as enhancers of yellow-1, 2, 3, 4 and 5 are directly or indirectly involved in control of the yellow locus expression.
本研究的目的是获得参与黄色基因座和mdg4调控的基因突变。为此，我们寻找能改变由mdg4插入黄色基因座调控区诱导的y(2)突变表型表达的突变。这些突变是在先前描述的长期基因组不稳定系统中获得的，有时与P-M杂种不育相结合。在一个新基因mdg4的修饰基因中检测到了mod(mdg4)突变，它增强或抑制了由mdg4插入诱导的几个突变的表型表达。我们认为mod(mdg4)控制mdg4的表达。此外，还发现位于X染色体上的五个基因座发生了突变，这些突变增强了由不同移动元件插入黄色基因座调控区诱导的几个y等位基因突变的表型。可能，这些被命名为黄色-1、2、3、4和5增强子的基因的蛋白质产物直接或间接参与黄色基因座表达的调控。
