Kalayanarooj Siripen, Rothman Alan L, Srikiatkhachorn Anon
Dengue Unit, Queen Sirikit National Institute of Child Health, Bangkok, Thailand; and.
Department of Cell and Molecular Biology and Institute for Immunology and Informatics, University of Rhode Island, Providence.
J Infect Dis. 2017 Mar 1;215(suppl_2):S79-S88. doi: 10.1093/infdis/jiw609.
The global burden of dengue and its geographic distribution have increased over the past several decades. The introduction of dengue in new areas has often been accompanied by high case-fatality rates. Drawing on the experience in managing dengue cases at the Queen Sirikit National Institute of Child Health in Bangkok, Thailand, this article provides the authors' perspectives on key clinical lessons to improve dengue-related outcomes. Parallels between this clinical experience and outcomes reported in randomized controlled trials, results of efforts to disseminate practice recommendations, and suggestions for areas for further research are also discussed.
在过去几十年中，登革热的全球负担及其地理分布都有所增加。登革热在新地区的出现往往伴随着高病死率。本文借鉴泰国曼谷诗丽吉王后国家儿童健康研究所管理登革热病例的经验，阐述了作者对于改善登革热相关预后的关键临床经验教训的看法。还讨论了这一临床经验与随机对照试验报告的结果、传播实践建议的努力成果之间的相似之处，以及对进一步研究领域的建议。
