家族性腺瘤性息肉病中的DNA非整倍体与细胞增殖
DNA aneuploidy and cell proliferation in familial adenomatous polyposis.
作者信息
Quirke P, Dixon M F, Day D W, Fozard J B, Talbot I C, Bird C C
机构信息
Department of Pathology, University of Leeds.
出版信息
Gut. 1988 May;29(5):603-7. doi: 10.1136/gut.29.5.603.
Abstract
Two hundred and thirteen samples from 20 patients with familial adenomatous polyposis (FAP) were investigated by flow cytometry and the results compared with 100 sporadic adenomas. Eleven of the 20 (55%) yielded one or more DNA aneuploid samples with an overall incidence within FAP adenomas of 12%. Despite a similar level of DNA aneuploidy in sporadic adenomas, it was commonly detected at a smaller polyp size. The degree of cell proliferation was found to be similar in the two groups (median %S+G2 15.8% v 16.4%) but larger FAP adenomas demonstrated a higher level of cell proliferation than smaller adenomas. DNA aneuploidy had no value as a predictor of a synchronous carcinoma and appeared to be an early change in the development of carcinoma in these patients.
摘要
采用流式细胞术对20例家族性腺瘤性息肉病（FAP）患者的213份样本进行了研究，并将结果与100份散发性腺瘤进行了比较。20例患者中有11例（55%）产生了一个或多个DNA非整倍体样本，FAP腺瘤的总体发生率为12%。尽管散发性腺瘤中的DNA非整倍体水平相似，但通常在息肉较小的时候就能检测到。发现两组的细胞增殖程度相似（S+G2期的中位数百分比分别为15.8%和16.4%），但较大的FAP腺瘤比较小的腺瘤表现出更高的细胞增殖水平。DNA非整倍体对同步癌没有预测价值，似乎是这些患者癌症发生过程中的早期变化。
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