Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
Institute of Model Animal, Wuhan University, Wuhan, People's Republic of China; and.
Physiology (Bethesda). 2017 May;32(3):210-223. doi: 10.1152/physiol.00038.2016.
Interferon regulatory factors (IRFs) are evolutionarily conserved proteins expressed not only in immune cells but also in other tissues and organs outside the immune system. In this review, we discuss mechanisms responsible for IRF-mediated innate immune responses and the function and mechanism of IRFs in cardiometabolic diseases. We focus on the role of IRFs in innate immunity and cardiometabolic homeostasis, and highlight reprogrammed IRF signaling.
干扰素调节因子（IRFs）是进化上保守的蛋白质，不仅在免疫细胞中表达，而且在免疫系统外的其他组织和器官中表达。在这篇综述中，我们讨论了负责 IRF 介导的先天免疫反应的机制以及 IRF 在心血管代谢疾病中的功能和机制。我们重点介绍了 IRF 在先天免疫和心血管代谢稳态中的作用，并强调了重新编程的 IRF 信号。
