长链非编码RNA TUG1通过上皮-间质转化途径促进结直肠癌转移。
Long non-coding RNA TUG1 promotes colorectal cancer metastasis via EMT pathway.
作者信息
Wang Liang, Zhao Zhenxian, Feng Weidong, Ye Zhijun, Dai Weigang, Zhang Changhua, Peng Jianjun, Wu Kaiming
机构信息
Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Biliary Pancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
Oncotarget. 2016 Aug 9;7(32):51713-51719. doi: 10.18632/oncotarget.10563.
Abstract
Colorectal cancer (CRC) is the third most common malignancy in developed countries, and its incidence rate has been continuously increasing in developing countries over the past few decades. Taurine-upregulated gene 1 (TUG1) plays an important role in signal transduction, regulation of cell morphology, migration, proliferation and apoptosis. The aim of the present study was to evaluate the role of TUG1 in CRC, and whether knockdown of TUG1 expression could affect cell proliferation, migration and invasion of CRC cell lines. Here, we reported that TUG1 was upregulated in CRC. Further experiments revealed that TUG1 knockdown significantly inhibited cell proliferation, migration and invasion of CRC in vitro. Above all, knockdown of TUG1 may represent a rational therapeutic strategy for CRC patients in future.
摘要
结直肠癌（CRC）是发达国家中第三大常见恶性肿瘤，在过去几十年里，其发病率在发展中国家持续上升。牛磺酸上调基因1（TUG1）在信号转导、细胞形态调控、迁移、增殖和凋亡中发挥重要作用。本研究的目的是评估TUG1在结直肠癌中的作用，以及TUG1表达的敲低是否会影响结直肠癌细胞系的细胞增殖、迁移和侵袭。在此，我们报道TUG1在结直肠癌中上调。进一步的实验表明，TUG1敲低在体外显著抑制了结直肠癌的细胞增殖、迁移和侵袭。最重要的是，TUG1敲低可能是未来结直肠癌患者的一种合理治疗策略。
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