Song Hao, Wang Lizhen, Lyu Jiong, Wu Yunteng, Guo Wei, Ren Guoxin
Department of Oral & Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200011, China.
Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200011, China.
Oncotarget. 2017 Apr 25;8(17):29080-29090. doi: 10.18632/oncotarget.16175.
Oral mucosal melanoma (OMM) is an aggressive neoplasm with an extremely poor prognosis. BAP1 is a tumor suppressor that has been associated with the outcome of melanomas and other malignancies. In this study, we investigated the genetic alterations in BAP1 and the prognostic potential of BAP1 protein expression in oral mucosal melanoma. DNA sequence analysis of BAP1 from 12 OMM patient samples revealed missense mutations in the tissues from four patients. Based on immunohistochemical staining, loss of nuclear BAP1 expression was associated with poor overall survival (P < 0.001, Log-rank = 21.308) and distant metastasis (P = 0.034, OR = 0.320). Multivariate analysis showed BAP1 to be an independent prognostic factor (P = 0.027, HR = 0.479). It thus appears that loss of nuclear BAP1 expression is an independent prognostic factor of poor overall survival and associated with distant metastasis in OMM.
口腔黏膜黑色素瘤（OMM）是一种侵袭性肿瘤，预后极差。BAP1是一种肿瘤抑制因子，与黑色素瘤及其他恶性肿瘤的预后相关。在本研究中，我们调查了BAP1的基因改变以及BAP1蛋白表达在口腔黏膜黑色素瘤中的预后潜力。对12例OMM患者样本的BAP1进行DNA序列分析，发现4例患者组织中有错义突变。基于免疫组化染色，细胞核BAP1表达缺失与总生存期差（P < 0.001，Log-rank = 21.308）和远处转移（P = 0.034，OR = 0.320）相关。多因素分析显示BAP1是一个独立的预后因素（P = 0.027，HR = 0.479）。因此，细胞核BAP1表达缺失似乎是OMM患者总生存期差的一个独立预后因素，并与远处转移相关。
