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磷酸化Akt1表达与皮肤、口腔和鼻窦黑色素瘤的不良预后相关。

Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas.

作者信息

Soares Ciro, Melo de Lima Morais Thayná, Carlos Roman, Mariano Fernanda Viviane, Altemani Albina, Freire de Carvalho Maria Goretti, Corrêa Marcelo Brum, Dias Dos Reis Rodrigo Ribas, Amorim Luciana Schultz, Paes de Almeida Oslei, Jorge Jacks

机构信息

Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

Pathology Division, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala.

出版信息

Oncotarget. 2018 Dec 18;9(99):37291-37304. doi: 10.18632/oncotarget.26458.

DOI:10.18632/oncotarget.26458
PMID:30647870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6324666/
Abstract

Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Similar to the metastatic cutaneous melanomas, p-Akt1 was overexpressed in 17/34 of the oral cavity and 20/31 of the sinonasal melanomas. In addition, the p-Akt1-nuclear expression was associated with poorer cancer-specific survival in cutaneous ( < .0001), oral ( < .0001), and sinonasal ( = .001) melanomas. Multivariate analysis showed p-Akt1 to be an independent prognostic marker in oral ( = .041) and sinonasal ( < .0001) melanomas patients. In conclusion, p-Akt1 overexpression is an independent prognostic marker in mucosal melanomas and is significantly up-regulated in sinonasal melanomas. As both mucosal and metastatic cutaneous melanomas showed high frequency of p-Akt1 expression, these findings suggest that mucosal melanomas have a biological behaviour, similar to the aggressive cutaneous melanomas.

摘要

黑色素瘤是源自黑素细胞的高度侵袭性肿瘤，最常见于皮肤。偶尔，这些肿瘤可能出现在口腔和鼻窦粘膜中。在本研究中，我们对144例皮肤黑色素瘤（CM）、34例口腔黑色素瘤（OM）和31例鼻窦黑色素瘤（SNM）患者的磷酸化Akt1（p-Akt1）表达进行了比较分析。与转移性皮肤黑色素瘤相似，p-Akt1在17/34的口腔黑色素瘤和20/31的鼻窦黑色素瘤中过表达。此外，p-Akt1的核表达与皮肤（<.0001）、口腔（<.0001）和鼻窦（=.001）黑色素瘤较差的癌症特异性生存率相关。多变量分析显示p-Akt1是口腔（=.041）和鼻窦（<.0001）黑色素瘤患者的独立预后标志物。总之，p-Akt1过表达是粘膜黑色素瘤的独立预后标志物，且在鼻窦黑色素瘤中显著上调。由于粘膜和转移性皮肤黑色素瘤均显示出高频率的p-Akt1表达，这些发现表明粘膜黑色素瘤具有与侵袭性皮肤黑色素瘤相似的生物学行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4712/6324666/d370813ff41d/oncotarget-09-37291-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4712/6324666/087f4cfbea33/oncotarget-09-37291-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4712/6324666/8cd8aae57fb1/oncotarget-09-37291-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4712/6324666/cc19923feccd/oncotarget-09-37291-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4712/6324666/d370813ff41d/oncotarget-09-37291-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4712/6324666/087f4cfbea33/oncotarget-09-37291-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4712/6324666/8cd8aae57fb1/oncotarget-09-37291-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4712/6324666/cc19923feccd/oncotarget-09-37291-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4712/6324666/d370813ff41d/oncotarget-09-37291-g004.jpg

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