Department of Microbiology, University of Iowa, Iowa City, IA, USA.
Department of Pathology, University of Iowa, Iowa City, IA, USA.
Immunol Cell Biol. 2017 Sep;95(8):651-655. doi: 10.1038/icb.2017.32. Epub 2017 Apr 13.
In the light of new findings that lung tissue resident memory CD8 T cells (T) represent major mediators of heterosubtypic immunity against influenza virus, it is of utmost importance to understand the basic biological mechanisms behind induction, formation and maintenance of this cell population. Addressing these important knowledge gaps will potentially inform development of superior, broadly protective influenza vaccines and new immunization strategies.
鉴于新发现表明肺组织驻留记忆 CD8 T 细胞（T 细胞）是针对流感病毒产生异源免疫的主要介质，了解这种细胞群体产生、形成和维持的基本生物学机制至关重要。解决这些重要的知识空白，将有可能为开发更优、广泛保护的流感疫苗和新的免疫策略提供信息。
