Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Trends Immunol. 2017 Feb;38(2):94-103. doi: 10.1016/j.it.2016.11.004. Epub 2016 Dec 9.
Numerous innate and adaptive immune cells reside in non-lymphoid tissues, where they contribute to barrier immunity, tissue homeostasis, and immune regulation. These tissue-resident populations do not recirculate in the blood or lymphatics and adopt a unique phenotype that is distinct from immune cells in the circulation. Tissue residency has been predominantly described for memory CD8 T cells [tissue-resident memory T cells (T)], but it is now clear that CD4 T cells, regulatory T (Treg) cells, various innate T cells, and innate lymphoid cells (ILCs) can establish residence in non-lymphoid tissues. Here we highlight distinct and common features of tissue-resident lymphocytes, with a focus on the transcriptional programs that have recently been shown to guide the establishment of tissue residency.
许多先天和适应性免疫细胞存在于非淋巴组织中，在那里它们有助于屏障免疫、组织稳态和免疫调节。这些组织驻留群体不会在血液或淋巴中循环，并且具有独特的表型，与循环中的免疫细胞不同。组织驻留主要是针对记忆 CD8 T 细胞 [组织驻留记忆 T 细胞 (T)] 描述的，但现在很清楚，CD4 T 细胞、调节性 T (Treg) 细胞、各种先天 T 细胞和先天淋巴细胞 (ILC) 可以在非淋巴组织中建立驻留。在这里，我们重点介绍组织驻留淋巴细胞的独特和共同特征，特别关注最近显示可指导组织驻留建立的转录程序。
