Domschke Pia, Trucu Dumitru, Gerisch Alf, Chaplain Mark A J
Fachbereich Mathematik, Technische Universität Darmstadt, Dolivostr. 15, 64293, Darmstadt, Germany.
Division of Mathematics, University of Dundee, Dundee, DD1 4HN, UK.
J Math Biol. 2017 Dec;75(6-7):1517-1561. doi: 10.1007/s00285-017-1120-y. Epub 2017 Apr 12.
The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with three examples arising from cancer invasion.
集体细胞运动与伴随的细胞信号传导机制中涉及的各种分子之间的动态相互作用，在许多生物学过程中起着至关重要的作用，包括正常组织发育以及诸如伤口愈合和癌症等病理情况。有关这些过程中嵌入的各种结构的信息，有助于详细探究分子种类与不断演变的细胞群体内细胞表面受体的结合情况。在本文中，我们建立了一个通用的时空结构框架，该框架能够描述分子与细胞膜的结合以及细胞群体动态。我们首先对这种方法进行一般性的理论描述，然后通过癌症侵袭产生的三个例子对其进行说明。
